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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (8): 76-83    DOI: 10.13523/j.cb.20180810
综述     
力学微环境影响间充质干细胞分化的研究现状 *
施文雯1,2,张蕾2,**()
1. 昆明医科大学 昆明 650011
2. 昆明医科大学附属甘美医院(昆明市第一人民医院)生物医学实验中心 昆明 650011
Current Research of Micro Mechanical Environmental Effects on Mesenchymal Stem Cells’ Differentiation
Wen-wen SHI1,2,Lei ZHANG2,**()
1. Kunming Medical University, Kunming 650011, China
2. Biomedical Research Center, Affiliated Calmette Hospital of Kunming Medical University (First Hospital of Kunming), Kunming 650011, China
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摘要：

间充质干细胞(mesenchymal stem cells, MSCs) 具有很强的自我复制能力和多向分化潜能,是近年来热门研究的种子细胞。MSCs的生长微环境可以影响调控干细胞的生长、分化,力学刺激是MSCs分化的影响因素之一。细胞外基质硬度、机械应力(剪切力、静压力、牵张力)、微重力等因素对MSCs的分化作用是当前研究的热点。就细胞外基质硬度、机械应力以及机械应力作用于三维支架培养对MSCs分化的影响等方面进行综述。
关键词： 力学刺激;  间充质干细胞;  细胞分化    
Abstract:

Mesenchymal stem cells (MSCs) have capacity of self-amplification and multi-direction differentiation, which is a hot research topic as popular seeding cell in recent years. It is well known that micro-environment modulates MSCs’ development and differentiation. Mechanical stimulation is one of the factors effecting on MSCs’ differentiation. The effect of extracellular matrix stiffness and mechanical stress, like shearing stress, hydrostatic pressure, stretch stress, and microgravity on MSCs remains a hot point. In the present article, the effects of external matrix stiffness, mechanical stress and the mechanical force on three-dimensional scaffolds on the MSCs’ differentiation were mainly reviewed.
Key words: Mechanical stimulation    Mesenchymal stem cells    Cell differentiation
收稿日期: 2018-04-04 出版日期: 2018-09-11
ZTFLH:  Q233  
基金资助: 国家自然科学基金(81660303)
通讯作者: 张蕾     E-mail: zlei01@hotmail.com
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引用本文:

施文雯,张蕾. 力学微环境影响间充质干细胞分化的研究现状 *[J]. 中国生物工程杂志, 2018, 38(8): 76-83.

Wen-wen SHI,Lei ZHANG. Current Research of Micro Mechanical Environmental Effects on Mesenchymal Stem Cells’ Differentiation. China Biotechnology, 2018, 38(8): 76-83.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180810    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I8/76

图1  机械刺激在三维支架中影响MSCs分化的模式图
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