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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2021, Vol. 41 Issue (7): 74-80    DOI: 10.13523/j.cb.2103028
综述     
MiR-148生物学功能研究进展*
王宇轩,陈婷,张永亮()
华南农业大学动物科学学院 广州 510642
Research Progress on the Biological Function of MiR-148
WANG Yu-xuan,CHEN Ting,ZHANG Yong-liang()
College of Animal Science, South China Agricultural University, Guangzhou 510642, China
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摘要：

microRNA(miRNA)是一种分布广泛、功能多样、在物种间高度保守的非编码单链RNA。miRNA可通过与目标mRNA的3'非编码区(3'UTR)完全或不完全靶向结合来调控基因的表达,在转录水平发挥调控作用。miRNA以稳定的形式存在于各种体液中,可作为不同生理或病理状态下的生物标志物。基于前期高通量测序发现miR-148在猪初乳与常乳外泌体中差异表达,拟从免疫、肿瘤及其他生物学功能,综述miR-148相关研究进展,以期为乳汁外泌体运载miR-148发挥生物学功能的研究提供参考。
关键词： 间充质干细胞;  外泌体;  炎症性肠病;  miR-148;  生物学功能;  靶基因    
Abstract:

MicroRNA (miRNA) is a non-coding single-stranded RNA that is widely distributed, diverse in functions, and highly conserved among species. MiRNA can regulate gene expression by completely or incompletely targeting the 3'non-coding region (3' UTR) of target mRNA, and play a regulatory role at the transcriptional level. At the same time, miRNA exists in various body fluids in a stable form, and can be used as a biomarker under different physiological or pathological conditions. Based on the early high-throughput sequencing found that miR-148 is differentially expressed in porcine colostrum and normal milk exosomes, this article intends to review the progress of miR-148 related research in terms of immunity, tumors and other biological functions, with the hope that it provides reference for the study on the biological functions of miR-148 carried by exosomes.
Key words: Mesenchymal stem cells    Exosomes    Inflammatory bowel disease    MiR-148    Biological function    Target gene
收稿日期: 2021-03-15 出版日期: 2021-08-03
ZTFLH:  R574.62  
基金资助: * 国家自然科学基金资助项目(31872973);* 国家重点研发计划(2016YFD0500503);国家自然科学基金(31802156);国家自然科学基金(2072812);广东省自然科学基金资助项目(2019A1515011734)
通讯作者: 张永亮     E-mail: zhangyl@scau.edu.cn
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王宇轩,陈婷,张永亮. MiR-148生物学功能研究进展*[J]. 中国生物工程杂志, 2021, 41(7): 74-80.

WANG Yu-xuan,CHEN Ting,ZHANG Yong-liang. Research Progress on the Biological Function of MiR-148. China Biotechnology, 2021, 41(7): 74-80.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2103028    或    https://manu60.magtech.com.cn/biotech/CN/Y2021/V41/I7/74

序号 人乳 猪乳 牛乳 大熊猫 袋鼠
1 MiR-148a-3p MiR-148a-3p MiR-148a Let-7b-5p MiR-181
2 MiR-30b-5p MiR-30a-5p Let-7a-5p MiR-92a-1&-2-3p Let-7f
3 Let-7f-5p&-2-5p MiR-25-5p Let-7b MiR-148a-3p MiR-22
4 MiR-146b-5p MiR-182-5p MiR-21-5p MiR-30a-5p MiR-10a
5 MiR-29a-3p MiR-30d-5p MiR-99a-5p MiR-7a-1/-2/-3-5p MiR-148a
6 Let-7a-2-5p&-3-5p MiR-574-3p Let-7f MiR-181a-1/-2-5p MiR-30a
7 MiR-141-3p MiR-30c-2-5p&-1-5p Let-7c Let-7i-5p MiR-184
8 MiR-182-5p MiR-200c-3p MiR-200c Let-7f-1/-2-5p MiR-375
9 MiR-200a-3p MiR-191-5p MiR-26a Let-7g-5p MiR-191
10 MiR-378-3p MiR-7a-1-5p MiR-30d MiR-21-5p MiR-10b
表1  不同物种乳汁外泌体丰富度排名前10的miRNAs
图1  MiR-148家族前体
图2  MiR-148在免疫中的部分调控作用
物种 名称 靶基因 细胞 生物学作用 参考文献
鼠 MiR-148a ITGA9 胶质母细胞瘤细胞 抑制胶质母细胞瘤的增殖和迁移 [39]
鼠 MiR-148a-3p PTEN 肾小球细胞 抑制狼疮性肾炎中肾小球细胞的增殖 [40]
人 MiR-148a MSK1 前列腺上皮细胞 抑制细胞生长以及细胞迁移 [41]
鼠 MiR-148a KLF4 前列腺癌细胞 抑制前列腺癌细胞生长 [42]
人 MiR-148a AKT2 肾细胞癌细胞 抑制肾细胞癌增殖和迁移 [43]
人 MiR-148a MAP3K9 食管鳞状细胞癌细胞 抑制食道鳞状细胞癌细胞增殖和迁移 [30]
人 MiR-148a SMAD2 胃癌细胞 抑制胃癌细胞的转移 [44]
鼠 MiR-148a HPIP 肝癌细胞 抑制肝癌细胞的生长和转移 [45]
人 MiR-148a MET 肝癌细胞 抑制肝癌细胞的增殖与转移 [46]
人 MiR-148a CCKBR;Bcl-2 胰腺癌细胞 胰腺癌细胞的增殖 [47]
人 MiR-148a CAND1 前列腺癌细胞 促进前列腺癌细胞的增殖 [48]
人 MiR-148a-3p DNMT1 胶质母细胞瘤细胞 抑制胶质母细胞瘤细胞生长与迁移 [49]
表2  MiR-148在肿瘤中的研究
物种 名称 靶基因 细胞 生物学作用 参考文献
兔 MiR-148a-3p PTEN 脂肪细胞 促进脂肪细胞的分化 [56]
鸡 MiR-148a-3p Meox2 骨骼肌卫星细胞 促进骨骼肌卫星细胞的分化和抑制细胞凋亡 [57]
牛 MiR-148a-3p KLF6 肌肉细胞 抑制牛肌肉细胞的增殖并促进细胞凋亡 [58]
人、小鼠 MiR-148a DNMT1 肝细胞 促进白肝脏蛋白产生 [59]
人 MiR-148a DNMT1 间充质干细胞 促进心肌间充质干细胞分化 [60-61]
表3  MiR-148在其他生物学过程中的研究
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