Progress in the Synthesis of Tetraterpenes by Microorganisms

doi:10.13523/j.cb.2304024

China Biotechnology

2023, Vol. 43

Issue (10): 96-108 DOI: 10.13523/j.cb.2304024

Progress in the Synthesis of Tetraterpenes by Microorganisms

ZHENG Li-ming,WANG Peng-chao^**(

)

Aulin College, Northeast Forestry University, Harbin 150040, China

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Abstract

Tetrapenoids, mainly carotenoids, are widely used in medical and food applications due to their antioxidant, anti-inflammatory, and anti-cancer properties, but traditional methods of extraction from natural products and chemical synthesis have many limitations and are not conducive to industrial mass production due to high costs or poor product activity and purity. In recent years, microbial synthesis has become a trend for synthesizing high-value products based on gene editing and other technologies. This review introduces the main pathways of carotenoid biosynthesis, reviews the progress of carotenoid synthesis in different types of chassis strains in recent years, and summarizes the main optimization strategies used in current research. It shows the recent progress of carotenoid synthesis by microorganisms and the advantages and disadvantages of the comparison between different types of chassis bacteria by comparing the synthesis strategies and yields of different strains, and points out the development direction to further improve the titer of target products by summarizing the main optimization methods. It provides more references for the subsequent research related to the synthesis of carotenoids by microorganisms.

Key words： Tetrapenoid Carotenoid Biosynthesis Optimization method

Received: 12 April 2023 Published: 02 November 2023

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Cite this article:

ZHENG Li-ming, WANG Peng-chao. Progress in the Synthesis of Tetraterpenes by Microorganisms. China Biotechnology, 2023, 43(10): 96-108.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2304024 OR https://manu60.magtech.com.cn/biotech/Y2023/V43/I10/96

Fig.1 Chemical structure of some carotenoids

Fig.2 The first stage of tetriterpenoid biosynthesis

Fig.3 The second stage of tetriterpenoid biosynthesis

Fig.4 Chemical structure of some tetriterpenoids modified products

Table 1 Bacteria that naturally synthesize carotenoids

Table 2 Algae that naturally synthesize carotenoids

Table 3 Fungi that naturally synthesize carotenoids


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