Application of Immunoinformatics in Epitope Vaccine Development

doi:10.13523/j.cb.2301022

China Biotechnology

2023, Vol. 43

Issue (7): 88-100 DOI: 10.13523/j.cb.2301022

Application of Immunoinformatics in Epitope Vaccine Development

Hong-sheng FENG^1,²,Hang JIN^1,²,Yong-yu GAO³,Yu-han XIAN^1,²,Hai-yang LI^1,²,Si-yu YANG^1,²,Ai-ming JIA^4,^**(

),Feng-shan GAO^1,^2,^**(

)

1 College of Life and Health, Dalian University, Dalian 116622, China
2 The Dalian Gene and Protein Engineering for Drug Screening Key Laboratory, Dalian 116622, China
3 College of Veterinary Medicine, Jilin Agricultural University, Changchun 130118, China
4 The Second Hospital of Dalian Medical University, Dalian 116027, China

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Abstract

Presently, to design epitope vaccines, the research and development process is generally to use computer-aided immunoinformatics tools and related technical methods to analyze acquired or known nucleotide and amino acid sequences to determine and pre-screen out possible dominant epitopes, and then prepare polypeptide vaccines with dominant epitopes through synthetic or genetic engineering techniques. The rapid development of immunoinformatics has been successfully applied to the field of vaccinology, and the immunoinformatics method is the most effective method to develop vaccines based on epitope polypeptide. Immunoinformatics, the general process of immunoinformatics in epitope vaccine design and validation, the immunoinformatics tools involved in the design of epitope vaccines, and the specific application of immunoinformatics in the design of epitope vaccines are reviewed, which will provide reference for reasonable design and development of effective epitope vaccines.

Key words： Immunoinformatics Epitope peptides Epitope vaccines

Received: 15 January 2023 Published: 03 August 2023

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	Articles by authors
	Hong-sheng FENG
	Hang JIN
	Yong-yu GAO
	Yu-han XIAN
	Hai-yang LI
	Si-yu YANG
	Ai-ming JIA
	Feng-shan GAO

Cite this article:

Hong-sheng FENG, Hang JIN, Yong-yu GAO, Yu-han XIAN, Hai-yang LI, Si-yu YANG, Ai-ming JIA, Feng-shan GAO. Application of Immunoinformatics in Epitope Vaccine Development. China Biotechnology, 2023, 43(7): 88-100.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2301022 OR https://manu60.magtech.com.cn/biotech/Y2023/V43/I7/88

Fig.1 The general flow chart for designing epitope vaccines using immunoinformatics

Table 1 Common validation methods used after vaccine development

Table 2 Part of the online tools for T-cell epitope prediction

Table 3 Part of the online tools for B-cell epitope prediction

Table 4 Part of the online tools for epitope analysis

Table 5 Online tool for structural prediction of vaccine constructs

Table 6 Molecular docking online access tools

Fig.2 The flow chart for the design of a multi-epitope peptide vaccine against DENV

Fig.3 The flow chart for design of a multi-epitopes candidate vaccine against Brucella

Fig.4 The flow chart for design of a multi-epitope candidate vaccine against Toxoplasma gondii infection

Fig.5 The flow chart for design of a novel PD-1 B-cell peptide epitope vaccine

Fig.6 The flow chart for design of a multi-epitope vaccine design for Amb a 11


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