Research Progress on the Function of Pro-apoptotic Protein BAK and Its Role in Virus Infection

doi:10.13523/j.cb.2208021

China Biotechnology

2023, Vol. 43

Issue (2/3): 130-140 DOI: 10.13523/j.cb.2208021

Research Progress on the Function of Pro-apoptotic Protein BAK and Its Role in Virus Infection

XU Wei-min,DENG Xin,WU Rui^**(

)

Research Center of Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 610000, China

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Abstract

BAK protein, a member of the BCL-2 family, is a key protein in the apoptosis pathway. It is activated under the stimulation of apoptotic signals, and after clustering on mitochondria, induces the release of cytochrome c and other pro-apoptotic substances, amplifies apoptosis signals through caspase cascade reaction, and finally promotes cell death. At present, the role of BAK in the apoptosis escape of cancer cells and the activation of intracellular inflammatory response has been confirmed, but the mechanism of action between viruses and other pathogens and BAK, the activation process of intracellular apoptosis and inflammatory pathways are less studied. Therefore, in this paper, the structure and function of BAK protein and the related pathways mediated by BAK are introduced, and the progress of its role in the study of virus infection is analyzed, in order to provide some theoretical basis for the in-depth study of the pro-apoptotic protein BAK in virus infection.

Key words： Pro-apoptotic protein BAK Apoptosis BCL protein family Viral infection

Received: 15 August 2022 Published: 31 March 2023

ZTFLH:

Q946.1

Corresponding Authors: **Rui WU E-mail: wurui1977@163.com

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Cite this article:

XU Wei-min, DENG Xin, WU Rui. Research Progress on the Function of Pro-apoptotic Protein BAK and Its Role in Virus Infection. China Biotechnology, 2023, 43(2/3): 130-140.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2208021 OR https://manu60.magtech.com.cn/biotech/Y2023/V43/I2/3/130

Fig.1 Structure of BAK protein (image made by PyMol Protein Structure Prediction software)

Fig.2 BAK protein activation form

Fig.3 The expression regulation mechanism of BAK

Table 1 BAK in the study of virus infection


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