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中国生物工程杂志

China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (12): 118-128    DOI: 10.13523/j.cb.20141217
    
Development in Breeding of Butanol Producing Strain
LIN Jun-han, QIU Dong-feng, LIN Chen
Fujian Vocational College of Bioengineering, Fuzhou 350002, China
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Abstract  

The biobutanol industry is limited by yield, productivity and low proportion in acetone-butanol-ethanol fermentation. Strain improvement is considered as an important and basic strategy to solve the problems. In industry, many high-yield strains were obtained mainly by mutation breeding, in which compound mutation and rational screening are more efficient strategies. Genetic engineering breeding has achieved rapid development. The high-yield strains could be obtained by modification of the butanol pathway and other genes which inhibit butanol synthesis in Clostridium acetobutylicum, as well as construction and optimiztion of the butanol pathway in E. coli. However, the effects were still lower than those of mutation breeding. The most important strategy would be still to increase yield and proportion of butanol in the following strain improvement.



Key wordsButanol      Clostridium acetobutylicum      Mutation breeding      Genetic engineering breeding     
Received: 12 August 2014      Published: 25 December 2014
ZTFLH:  Q819  
Cite this article:

LIN Jun-han, QIU Dong-feng, LIN Chen. Development in Breeding of Butanol Producing Strain. China Biotechnology, 2014, 34(12): 118-128.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20141217     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I12/118


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