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| Express and Regulation of Animal Anti-hypoxia Stress-related Genes |
| FANG Song-gang1, LIU Di-qiu1, LI Zhong2, ZOU Gui-wei2, WANG Guang-yong1, TIAN Rong-huan1 |
1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China;
2. Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Jingzhou 434001, China |
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Abstract Maintenance of oxygen homeostasis is important to cellular and systemic function. Under hypoxia condition, a powerful defense of organism is triggered by the hypoxia signal to protect tissue and organs. In the process of defense, some genes are up-regulated, such as hypoxia inducible factor-1 (HIF-1)、vascular endothelial growth factor (VEGF)、erythropoietin (EPO) and nuclear factor-κB (NF-κB). HIF-1 is a anti-hypoxia stress-related genes and encodes a transcription factor, The regulation of HIF-1 activity is related to the oxygen concentration. VEGF is a target gene of HIF-1, which is one of the most critical antigenic factor identified to date. EPO can promote the differentiation and proliferation of red blood cells under hypoxia conditions. NF-κB can inhibit cell apoptosis which is induced by hypoxia. Obviously, these genes play important roles in protecting organism from hypoxia stress. The function, expression pattern and regulation mechanism of HIF-1, VEGF, NF-κB and EPO in hypoxia are summarized.
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Received: 01 June 2010
Published: 25 October 2010
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Corresponding Authors:
LIU Di-qiu
E-mail: diqiuliu@gmail.com
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