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中国生物工程杂志

China Biotechnology
China Biotechnology  2009, Vol. 29 Issue (08): 102-106    DOI:
    
Advances and Applications of Recombinant Antibody Drugs
 ZHANG Ying1, HE Jin-Sheng1, HONG Chao1,2
1.College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing100044,China
2.Institute for Viral Disease Control and Prevention, China CDC, Beijing100052,China
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Abstract  

Recombinant antibody drugs has developed through mice monoclonal antibody(McAb), humanmice chimeric antibody, humanized antibody and full human antibody. They have been applied in clinical immunotherapy for the treatment of cancer, autoimmune diseases, viral diseases and Alzheimer disease, etc. The two basic principles in antibody humanization are keeping or enhancing affinity and reducing immunogenicity of engineered antibodies. The degree of humanization has approached 100% following the continuously improved techniques, such as CDR grafting, resurfacing, antibody library and transgenic mice. However, the gap between the basic research and clinical application still need to be filled. The outline, challenge and perspective in application associated to recombinant antibody drugs were reviewed here.



Key wordsRecombinant antibody drugs      Monoclonal antibody humanization     
Received: 15 April 2009      Published: 28 July 2009
ZTFLH:  Q819  
Corresponding Authors: Ying Zhang   
Cite this article:

ZHANG Ying, HE Jin-Sheng, HONG Chao. Advances and Applications of Recombinant Antibody Drugs. China Biotechnology, 2009, 29(08): 102-106.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2009/V29/I08/102

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