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| The Development of the Study on bFGF Promote the Nerve Injury Repair |
| ZHANG Chao1, XIANG Li-na1, CHEN De-pei1, LÜ Xin-xin1, ZHAO Yi-tong1, WANG Lu-yao1, XIAO Jian1,2, ZHANG Hong-yu1,2 |
1. College of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China;
2. Zhejiang Provincial Key Laboratory of Biotechnology Pharmaceutical Engineering, Wenzhou 325035, China |
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Abstract Basic fibroblast growth factor(bFGF) is part of the fibroblast growth factor (FGFs) family.bFGF is unique in that it is expressed both in the animal and human model but has also garnered attention for its extensive physiological functions and important clinical applications. Current evidence suggests that bFGF may play a prominent role in nerve cell regeneration, due to its pluripotent effects and neurotrophic action. Although it is already extensively studied in various disease states, there still remains much to be discovered about the functions and mechanisms in nerve regeneration of bFGF. The following review summarizes the current knowledge on bFGF with a special emphasis on central nervous system and peripheral nervous system disease.
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Received: 29 March 2015
Published: 25 June 2015
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