Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (11): 83-87    DOI:
    
Advances in the Serum Secretome of Cancer
DENG Meng-yao, CAO Ya
Cancer Research Institute, Central South University, Changsha 410078,China
Download: HTML   PDF(422KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

With the end of human genome sequencing project, the research of gene product becomes a hotspot, thus lead the rapid development of proteomic. Serum secretome plays a significant role in cancer. So far, many secretary proteins are considered as tumor biomarks and used for clinical detection.The basic research methods and latest advance in serum secretome of cancer were reviewed.



Key wordsSerum secretome      Cancer      Tumor markers      Therapeutic target     
Received: 16 July 2010      Published: 19 November 2010
ZTFLH:  R318  
Cite this article:

DENG Meng-yao, CAO Ya. Advances in the Serum Secretome of Cancer. China Biotechnology, 2010, 30(11): 83-87.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I11/83

[1] Wu H Y.Chang Y H.Chang Y C, et al., Proteomics analysis of nasopharyngeal carcinoma cell secretome using a hollow fiber culture system and mass spectrometry. J Proteome Res, 2009,8(1): 380-389.
[2] Cao J,Hu Y,Shen C, et al., Nanozeolite-driven approach for enrichment of secretory proteins in human hepatocellular carcinoma cells. Proteomics, 2009,9(21): 4881-8488.
[3] Mbeunkui F, Fodstad O, Pannell L K. Secretory protein enrichment and analysis: an optimized approach applied on cancer cell lines using 2D LC-MS/MS. J Proteome Res, 2006,5(4): 899-906.
[4] Lai T C,Chou H C,Chen Y W, et al.Secretomic and proteomic analysis of potential breast cancer markers by two-dimensional differential gel electrophoresis. J Proteome Res,2010,9(3): 1302-1322.
[5] Gronborg M,Kristiansen T Z,Iwahori A,et al. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics, 2006,5(1): 157-171.
[6] Chenau J,Josserand V, Michelland S,et al. The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells. J Proteome Res, 2009, 8(10): 4579-4591.
[7] Xue H,Lu B,Zhang J, et al. Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach. J Proteome Res,2010,9(1): 545-555.
[8] Wu C C,Chen H C,Chen S J, et al. Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes. Proteomics, 2008,8(2): 316-332.
[9] Ma Y,Peng J,Huang L,et al. Searching for serum tumor markers for colorectal cancer using a 2-D DIGE approach. Electrophoresis, 2009,30(15): 2591-2599.
[10] Kim J E,Koo K H,Kim Y H,et al. Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model. Exp Mol Med, 2008,40(6): 709-720.
[11] Rodriguez-Pineiro A M, Blanco-Prieto S, Sanchez-Otero N,et al. On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. J Proteomics,2010,73(8):1511-1522.
[12] Yang Y,Zhao S,Fan Y, et al. Detection and identification of potential biomarkers of non-small cell lung cancer. Technol Cancer Res Treat, 2009,8(6): 455-466.
[13] Wu C C,Hsu C W,Chen C D, et al. Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol Cell Proteomics,2010,9(6):1100-1117.
[14] Wang C L,Wang C I,Liao P C, et al.Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome. J Proteome Res, 2009,8(10): 4428-4440.
[15] Lou X,Xiao T,Zhao K, et al.Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer. J Proteome Res, 2007,6(3): 1083-1092.
[16] Chang Y H,Wu C C,Chang K P, et al. Cell secretome analysis using hollow fiber culture system leads to the discovery of CLIC1 protein as a novel plasma marker for nasopharyngeal carcinoma. J Proteome Res, 2009, 8(12): 5465-5474.
[17] Cheng A L,Huang W G,Chen Z C, et al.Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis. Clin Cancer Res, 2008,14(2): 435-445.
[18] Wu C C,Chien K Y,Tsang N M, et al.Cancer cell-secreted proteomes as a basis for searching potential tumor markers: nasopharyngeal carcinoma as a model. Proteomics, 2005,5(12): 3173-31782.
[19] Weng L P,Wu C C,Hsu B L, et al.Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility. J Proteome Res, 2008,7(9): 3765-3775.
[20] Kobayashi R,Deavers M,Patenia R, et al.14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients. Cancer Immunol Immunother, 2009,58(2): 247-258.
[21] Moscova M,Marsh D J, Baxter R C. Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines. Cancer Res, 2006, 66(3): 1376-1383.
[22] Chen R,Pan S,Cooke K, et al.Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis. Pancreas, 2007,34(1): 70-79.
[23] Yamashita R,Fujiwara Y,Ikari K et al.Extracellular proteome of human hepatoma cell, HepG2 analyzed using two-dimensional liquid chromatography coupled with tandem mass spectrometry. Mol Cell Biochem, 2007,298(1-2): 83-92.
[24] Sarkissian G,Fergelot P,Lamy P J, et al. Identification of pro-MMP-7 as a serum marker for renal cell carcinoma by use of proteomic analysis. Clin Chem, 2008,54(3): 574-581.
[25] Mbeunkui F, Metge B J,Shevde L A,et al. Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer. J Proteome Res, 2007,6(8): 2993-3002.
[26] Sardana G,Jung K,Stephan C, et al. Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers. J Proteome Res, 2008, 7(8): 3329-3338.
[27] Sardana G, Marshall J,Diamandis E P.Discovery of candidate tumor markers for prostate cancer via proteomic analysis of cell culture-conditioned medium. Clin Chem, 2007,53(3): 429-437.
[28] Pang B,Zhang H,Wang J, et al.Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression. Prostate, 2009,69(11): 1176-1187.
[29] Paulitschke V,Kunstfeld R,Mohr T,et al. Entering a new era of rational biomarker discovery for early detection of melanoma metastases: secretome analysis of associated stroma cells. J Proteome Res, 2009,8(5): 2501-2510.
[30] Mathias R A,Wang B,Ji H, et al.Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition. J Proteome Res, 2009,8(6): 2827-2837.
[31] Roomi M W, Monterrey J C. Kalinovsky T,et al.Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncol Rep, 2009,22(6): 1283-1291.
[32] Dai J,Li B,Shi J, et al.A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo. Cancer Immunol Immunother. 59(3): 355-366.
[33] Ohno K,Nishimori H,Yasoshima T,et al. Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model. Surg Today,2010,40(4): 347-356.

[1] YANG Wan-bin,XU Yan,ZHUO Shi-xuan,WANG Xin-yi,LI Ya-jing,GUO Yi-fan,ZHANG Zheng-guang,GUO Yuan-yuan. Progress of Long Non-coding RNAs Related Epigenetic Modifications in Cancer[J]. China Biotechnology, 2021, 41(8): 59-66.
[2] DONG Xue-ying,LIANG Kai,YE Ke-ying,ZHOU Ce-fan,TANG Jing-feng. Advances in the Regulation of Receptor Tyrosine Kinase on Autophagy[J]. China Biotechnology, 2021, 41(5): 72-78.
[3] LU Yu-xiang,LI Yuan,FANG Dan-dan,WANG Xue-bo,YANG Wan-peng,CHU Yuan-kui,YANG Hua. The Role and Expression Regulation of MiR-5047 in the Proliferation and Migration of Breast Cancer Cells[J]. China Biotechnology, 2021, 41(4): 9-17.
[4] TANG De-ping,XING Meng-jie,SONG Wen-tao,YAO Hui-hui,MAO Ai-hong. Advance of microRNA Therapeutics in Cancer and Other Diseases[J]. China Biotechnology, 2021, 41(11): 64-73.
[5] TANG Min,WAN Qun,SUN Shi-lei,HU Jing,SUN Zi-jiu,FANG Yu-ting,ZHANG Yan. The Effects of Hsa-miR-5195-3p on the Proliferation, Migration and Invasion of Human Cervical Cancer SiHa Cells[J]. China Biotechnology, 2020, 40(4): 17-24.
[6] CHEN Xue-yan,ZHANG Na,CHEN Juan,YANG Yan-hong,ZHANG Ju-feng. Effect of Hsa-miR-411-3P on Gastric Cancer Cells and Related Mechanisms[J]. China Biotechnology, 2020, 40(4): 1-9.
[7] HUANG Sheng, YAN Qi-tao, XIONG Shi-lin, PENG Yi-qi, ZHAO Rui. Construction of CHD5 Gene Overexpressing Lentiviral Vector Based on CRISPR/Cas9-SAM System and the Effect of CHD5 on Proliferation, Migration and Invasion in T24 Cells[J]. China Biotechnology, 2020, 40(3): 1-8.
[8] HU Li-jun,DUAN Liang,HUANG Yi-yun,LIN Lu,HUANG Mao,CHEN Lu,PENG Qi,HU Qin,ZHANG Yan,ZHOU Lan. S100A9 Is Involved in Fusobacterium nucleatum-Induced Proliferation and Migration of Colon Cancer HCT116 and SW480 Cells[J]. China Biotechnology, 2020, 40(1-2): 84-91.
[9] FENG Xue-jiao,HOU Hai-long,YU Qiong,WANG Jun-shu. Market Analysis and Countermeasures of Cervical Cancer Vaccine in China[J]. China Biotechnology, 2020, 40(11): 96-101.
[10] Pan-hong ZHANG,Lian-lian LI,Xiu-mei ZHANG,Jia-jun CUI,Yin-jie JIANG. Advances in the Relationship Between microRNA and Chemotherapy Resistance of Lung Cancer[J]. China Biotechnology, 2019, 39(7): 79-84.
[11] Jie XIAN,Xue QIN,You-de CAO. Numb Inhibits the Ubiquitination Degradation of p53 by HDM2 in Triple-negative Breast Cancer[J]. China Biotechnology, 2019, 39(7): 1-7.
[12] Yu-feng ZHANG,Meng-jia XIE,Shu-lei ZHOU,Ling-ling XU,Tie-jun ZHAO. Application of Cell-penetrating Peptides in Tumor Targeted Therapy and Disease Diagnosis[J]. China Biotechnology, 2019, 39(6): 48-54.
[13] Wei-bing PAN,Peng ZHU,Qi-ang ZENG,Kai WANG,Song LIU. Diversity Analysis of 5 CDR3s of T Cell Receptor β Chain in Prostate Cancer[J]. China Biotechnology, 2019, 39(3): 7-12.
[14] Lin YANG,Yong-chao LI,Teng-hua ZHANG,Yi-xiao DENG,Jin YANG,Zhi-bo GAO. Comprehensive Evaluation is needed for Precision Diagnosis in Cancer Immunotherapies[J]. China Biotechnology, 2019, 39(2): 62-73.
[15] Xi-wen JIANG,Zi-wei DONG,Yue LIU,Xiao-ya ZHU. Reserch Progress on Biomarkers and Precision Medicine[J]. China Biotechnology, 2019, 39(2): 74-81.