表面等离子体共振生物传感器知识产权的发展态势研究<sup>*</sup>

doi:10.13523/j.cb.2305013

中国生物工程杂志

2023, Vol. 43

Issue (11): 116-126 DOI: 10.13523/j.cb.2305013

专利

表面等离子体共振生物传感器知识产权的发展态势研究^*

陈玉阳¹,刘家源²,黄子芹²,陈禹保³,徐文娟^2,^**(

),龙峰²

1 中国国家知识产权局北京 100088
2 中国人民大学北京 100874
3 中国医学科学院医学实验动物研究所北京 100021

Current Development of Intellectual Property Rights in Surface Plasmon Resonance Biosensor Technology

CHEN Yu-yang¹,LIU Jia-yuan²,HUANG Zi-qin²,CHEN Yu-bao³,XU Wen-juan^2,^**(

),LONG Feng²

1 China National Intellectual Property Administration, Beijing 100088, China
2 Renmin University of China, Beijing 100874, China
3 Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing 100021, China

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摘要：

表面等离子体共振生物传感器是基于表面等离子体共振(surface plasmon resonance,SPR)原理发展起来的新型生物传感技术,具有免标记、特异性强、灵敏度高、可实时动态检测等特点,在分子互作、药物筛选等领域具有独特优势。世界各国都在加紧布局SPR生物传感器技术的知识产权,我国近年来在该方向的知识产权申请量显著增加。基于IncoPat专利数据库,对SPR生物传感器技术的总体发展态势、知识产权布局、热点技术构成等进行深入分析,并对关键知识产权进行识别。研究结果表明,我国在SPR生物传感器领域的研究日益活跃,专利申请数量处于世界领先地位,但是存在原创性知识产权数量少、知识产权转化率有限、产品市场占有率偏低等问题。鉴于SPR生物传感器的广阔市场前景,提出了我国SPR生物传感器技术的未来发展战略。

关键词： 表面等离子体共振; 生物传感器; 专利分析; 知识产权

Abstract:

Surface plasmon resonance (SPR) biosensors are a new type of biosensor technology based on the principle of SPR. They have numerous advantages including non-labeling, strong specificity, high sensitivity, and real-time dynamic detection, especially for the field of biological molecule interaction, drug-screening, etc. Many countries are stepping up their layout of intellectual property rights (IPRs) for SPR biosensor technology. The number of China’s intellectual property applications has increased significantly in recent years. Based on the IncoPat patent database, this study conducts an in-depth analysis on the overall development trend, intellectual property layout, popular technologies of SPR biosensors, and the identification of key IPRs. The results show that the SPR biosensor technology in China is becoming an increasingly active area of research, and China is ranked among the world’s leading countries in terms of the number of patent applications in this regard. However, several problems still exist, such as a small number of original IPRs, limited conversion rate of IPRs, and low market share of products. In view of the broad market prospects of SPR biosensor technologies, future development strategies of SPR biosensor technologies in China are proposed.

Key words: Surface plasmon resonance (SPR) Biosensor Patent analysis Intellectual property rights (IPRs)

收稿日期: 2023-05-10 出版日期: 2023-12-01

ZTFLH:

Q81

基金资助: *国家重点研发计划(2022YFF0609102)

通讯作者: 徐文娟 E-mail: xuwenjuan@ruc.edu.cn

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引用本文:

陈玉阳,刘家源,黄子芹,陈禹保,徐文娟,龙峰. 表面等离子体共振生物传感器知识产权的发展态势研究^*[J]. 中国生物工程杂志, 2023, 43(11): 116-126.

CHEN Yu-yang,LIU Jia-yuan,HUANG Zi-qin,CHEN Yu-bao,XU Wen-juan,LONG Feng. Current Development of Intellectual Property Rights in Surface Plasmon Resonance Biosensor Technology. China Biotechnology, 2023, 43(11): 116-126.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2305013 或 https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I11/116

图1 SPR生物传感器原理示意图

图2 SPR生物传感器技术专利逐年申请量

图3 全球SPR生物传感器技术专利申请人国别排名

图4 各国在中国申请SPR生物传感器技术专利情况

图5 中国各省在华SPR生物传感器专利申请情况

表1 SPR生物传感器技术专利全球主要申请人

表2 SPR生物传感器技术专利在华主要申请人

图6 全球SPR生物传感器专利技术领域分布

图7 全球SPR生物传感器技术构成排名

图8 在华申请SPR生物传感器专利技术构成排名

图9 从专利中提取的关键词云图光纤SPR生物传播感(A),棱镜SPR生物传感器(B),光波导SPR生物传感器(C),光栅SPR生物传感器(D),LSPR生物传感器(E),SPR生物传感器(F)

表3 全球SPR生物传感器技术领域部分核心专利

表4 在华SPR生物传感器技术领域部分核心专利

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