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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2022, Vol. 42 Issue (10): 70-79    DOI: 10.13523/j.cb.2203059
综述     
骨髓间充质干细胞来源外泌体及其相关信号通路在激素性股骨头坏死中作用的研究进展*
毕煦昆1,郭成龙2,**(),赵建栋1,任行全1,柴威涛1
1.甘肃中医药大学 兰州 730000
2.甘肃中医药大学附属医院 兰州 730000
Research Progress of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells and Their Related Signal Pathways in Steroid-induced Necrosis of the Femoral Head
Xu-kun BI1,Cheng-long GUO2,**(),Jian-dong ZHAO1,Xing-quan REN1,Wei-tao CHAI1
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
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摘要：

骨髓间充质干细胞是具有多向分化能力的一种干细胞,近年来有关研究发现骨髓间充质干细胞分泌的外泌体具有促进损伤肌腱修复、血管生成、抑制氧化应激反应、保护神经细胞、促进软骨再生、调节骨代谢等功能。而激素性股骨头坏死是由于大量使用激素导致的股骨头无菌性坏死,其具体作用机制尚未阐明,相关信号通路,如Wnt/β-catenin、RANKL-RANK、PTEN/AKT、PI3K/AKT等通路在其中起着关键的作用,而这些信号通路的激活又与外泌体密切相关,综述了骨髓间充质干细胞来源外泌体及其相关信号通路在激素性股骨头坏死中作用的有关研究进展,以期对激素性股骨头坏死的防治及相关药物研发有一定指导意义。
关键词： 外泌体;  信号通路;  骨修复;  激素性股骨头坏死    
Abstract:

Bone marrow mesenchymal stem cells are a kind of stem cells with multi-directional differentiation ability. In recent years, relevant studies have found that the exosomes secreted by bone marrow mesenchymal stem cells promote the repair of injured tendons and angiogenesis, inhibit oxidative stress response, protect neurons, promote cartilage regeneration, and regulate bone metabolism in addition to its other functions. Steroid-induced femoral head necrosis is a kind of aseptic necrosis of the femoral head caused by massive use of hormones. Its specific mechanism has not been clarified, and related signal pathways play a key role, such as Wnt/ β- catenin, RANKL-RANK, PTEN/AKT, PI3K/AKT and other pathways, and the activation of these signal pathways is closely related to exosomes. This article reviews the relevant research progress of exosomes from bone marrow mesenchymal stem cells and related signal pathways in steroid-induced femoral head necrosis, in order to have certain guiding significance for the prevention and treatment of steroid-induced femoral head necrosis and the development of related drugs.
Key words: Exosomes    Signaling pathway    Bone repair    Steroid-induced necrosis of the femoral head
收稿日期: 2022-03-26 出版日期: 2022-11-04
ZTFLH:  Q819  
基金资助: * 甘肃省自然科学基金(18JR3RA074);兰州市2019年科技计划项目(2019-1-64)
通讯作者: 郭成龙     E-mail: 107228466@qq.com
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毕煦昆
郭成龙
赵建栋
任行全
柴威涛

引用本文:

毕煦昆,郭成龙,赵建栋,任行全,柴威涛. 骨髓间充质干细胞来源外泌体及其相关信号通路在激素性股骨头坏死中作用的研究进展*[J]. 中国生物工程杂志, 2022, 42(10): 70-79.

Xu-kun BI,Cheng-long GUO,Jian-dong ZHAO,Xing-quan REN,Wei-tao CHAI. Research Progress of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells and Their Related Signal Pathways in Steroid-induced Necrosis of the Femoral Head. China Biotechnology, 2022, 42(10): 70-79.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2203059    或    https://manu60.magtech.com.cn/biotech/CN/Y2022/V42/I10/70

图1  外泌体的形成过程
图2  外泌体的结构
来源于BMSCs-Exos不同的mRNA 对应的信号通路 作用机制
miR-135b
miR-144
miR -545-3p		 Wnt/β-catenin 加快 DNA 损伤修复 [37]
[40]
miR-218a MAPK 促进血管再生及免疫调节 [38]
miR-27a-3p ATF3 促进 MSCs 成骨分化,抑制成脂分化 [41]
MiR-let-7a HMGA2 抑制炎症反应 [42]
表1  有关BMSCs-Exos中不同的miRNA及对应通路
图3  外泌体与相关信号通路在SONFH骨修复中的机制
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