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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2023, Vol. 43 Issue (7): 114-121    DOI: 10.13523/j.cb.2212031
    
Biomimetic Nanomedicine Delivery System Preparation and Disease Therapy Application
Lin-ying LIU1,**(),Jie SHEN2,Liang CHEN1,Hu-cheng ZHANG1,Xin-ying ZHAO1
1 College of Bioengineering, Beijing Polytechnic, Beijing 100176, China
2 State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
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Abstract  

Nanodrug delivery systems are widely used in disease treatment due to their special physical and chemical properties. However, the traditional synthetic nanoparticles cannot cross the natural barrier, and it is difficult to escape immune surveillance, so they are not effective in clinical applications. Biomimetic nanoparticles are obtained by modification of natural materials or by chemical methods imitating the key characteristics of biological structures. They are similar to biologically related structures in chemistry, physics or morphology. Therefore, they exhibit excellent intelligent delivery performance in inert rejection, barrier overcoming and active effects, and can be used for more efficient and safe drug delivery. Biomimetic nano-drug delivery systems are divided into four categories: nano-drug delivery systems designed based on natural biological macromolecules, drug delivery systems related to cells and cell membranes, drug delivery systems of extracellular vesicles such as extracellular secretions, and nano drug delivery systems mimicking biological structures. The design principle of biomimetic nanoparticles used for drug delivery is summarized, the preparation methods of four kinds of biomimetic nanoparticle drug delivery systems are elaborated, the research progress of their application in rare diseases, neurodegenerative diseases, tumors, antiviral vaccine research and development and other targeted therapies is summarized, and the clinical application challenges, potential solutions and future research directions in this field are also discussed.

Key words： Biomimetic      Nanoparticle      Drug delivery      Disease treatment      Biomaterial     
Received: 23 December 2022      Published: 03 August 2023
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Lin-ying LIU
Jie SHEN
Liang CHEN
Hu-cheng ZHANG
Xin-ying ZHAO
Cite this article:

Lin-ying LIU, Jie SHEN, Liang CHEN, Hu-cheng ZHANG, Xin-ying ZHAO. Biomimetic Nanomedicine Delivery System Preparation and Disease Therapy Application. China Biotechnology, 2023, 43(7): 114-121.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2212031     OR     https://manu60.magtech.com.cn/biotech/Y2023/V43/I7/114

Fig.1 Basic units of biomimetic nanoparticle design
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