Interaction between Protein Corona and Nanoparticles

doi:10.13523/j.cb.1910045

China Biotechnology

2020, Vol. 40

Issue (4): 78-83 DOI: 10.13523/j.cb.1910045

Interaction between Protein Corona and Nanoparticles

CHU Yu-qi,LU Fei-fei,LIU Yang,HE Fang,WANG Da-zhuang,CHEN Li-jiang(

)

School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China

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Abstract

In recent years, although nanoparticles have made great progress in biomedical research, they rarely enter clinical trials. This is mainly due to the lack of understanding of the interaction between nanoparticles and the physiological environment and the limited understanding of the biological characteristics of nanoparticles after they enter the body. In the physiological environment, proteins adsorb on the surface of nanoparticles and form protein corona. The formation of this nanoparticles-protein corona complex seriously affects the biological characteristics of nanoparticles and restricts the clinical application of nanoparticles. Therefore, the interaction between protein corona and nanoparticles should be further studied. At present, the research on nanoparticle-protein corona complex is a relatively new field. This review summarizes the research status of protein corona, and focuses on the impact of the interaction between protein corona and nanoparticles. It also introduces methods to prevent and reduce the formation of protein corona, providing ideas for further research and development of nanoparticles.

Key words： Protein corona Nanoparticles Interaction

Received: 25 October 2019 Published: 18 May 2020

ZTFLH:

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Corresponding Authors: Li-jiang CHEN E-mail: chlj16@163.com

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	Yu-qi CHU
	Fei-fei LU
	Yang LIU
	Fang HE
	Da-zhuang WANG
	Li-jiang CHEN

Cite this article:

CHU Yu-qi,LU Fei-fei,LIU Yang,HE Fang,WANG Da-zhuang,CHEN Li-jiang. Interaction between Protein Corona and Nanoparticles. China Biotechnology, 2020, 40(4): 78-83.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.1910045 OR https://manu60.magtech.com.cn/biotech/Y2020/V40/I4/78

Fig.1 The formation of protein corona and “Vroman” effect


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