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| Progress of Long Non-coding RNAs Related Epigenetic Modifications in Cancer |
YANG Wan-bin1,XU Yan1,ZHUO Shi-xuan1,WANG Xin-yi1,LI Ya-jing1,GUO Yi-fan2,ZHANG Zheng-guang1,GUO Yuan-yuan1,**( ) |
1 School of Medicine & Holistic Integrative Medicine of Nanjing University of Chinese Medicine, Nanjing 210023, China
2 School of Pharmacy Nanjing University of Chinese Medicine, Nanjing 210023, China |
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Abstract Long non-coding RNAs (lncRNAs) are generally defined as RNA transcripts of more than 200 nucleotides in length with limited protein-coding capacity; however their functions are diverse and complex. Previous studies have demonstrated that lncRNAs are closely related to cancer development and are potential cancer regulators. lncRNAs can participate in the regulation of intracellular biological processes in different ways. It is a potential cancer regulator. Among them, lncRNAs can affect cancer progression mainly through regulating the level of epigenetic modification. Epigenetic modifications exist in the cells during the pathogenesis of cancer such as DNA modification, RNA modification, and post-translational modification of proteins including methylation, acetylation, phosphorylation, glycosylation, and ubiquitination, and the degree of abnormal modifications is different at different stages of cancer. This phenomenon will affect the biological processes of tumorigenesis. Studies have shown that lncRNAs can participate in the occurrence and development of cancer through self-modification or taking part in the epigenetic modification of other biomolecules. Therefore, the epigenetic modification lncRNAs participate in and the role of lncRNAs in epigenetic modification were reviewed. This paper explores how lncRNAs affect cancer progression through regulating the level of epigenetic modification in order to summarize and analyze the research progress and provide potential targets and biomarkers for cancer diagnosis and treatment.
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Received: 14 April 2021
Published: 31 August 2021
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Corresponding Authors:
Yuan-yuan GUO
E-mail: guoyy@njucm.edu.cn
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