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| Recent Advances in Biological Detoxification of Inhibitors in Lignocellulose Hydrolysate |
| ZHANG Dong-xu |
| The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China |
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Abstract Pretreatment of lignocellulose is an essential step for converting lignocellulose to value-added fuels and chemicals by microbial fermentation. However, during thermo-chemical pretreatment, such as acid hydrolysis and steam explosion, a lot of degradation products such as furans, organic acids and phenolics are formed or released due to the harsh conditions. These degradation products are potential inhibitors to microbial fermentation, leading to low product yield and productivity. A prospective method for removing these toxins is biological detoxification, which has the advantages of simple operation and less generation of waste. One possible biological method is to remove the inhibitors in lignocellulose hydrolysate before fermentation by using microbes or enzymes. Another way is to use the genetic engineered or adapted (evolutionary engineered) micro-organisms, which obtained the ability to detoxify the inhibitors, to improve the fermentation capability of lignocellulose hydrolysate. We will focus on the biological detoxification methods used to improve ligocellulosic ethanol productivity and yield.
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Received: 11 June 2012
Published: 25 May 2013
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