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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2021, Vol. 41 Issue (5): 105-113    DOI: 10.13523/j.cb.2101019
    
Research Progress of Itaconic Acid Fermentation
GAO Yin-ling,ZHANG Feng-jiao,ZHAO Gui-zhong,ZHANG Hong-sen,WANG Feng-qin(),SONG An-dong
College of Life Sciences, Henan Agriculture University, Zhengzhou 450002, China
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Abstract  

Itaconic acid, a platform chemical, can be widely applied in various industries for kinds of high value-added products. It is one of the potential alternatives to the traditional petroleum-based material, which has an important position and application prospect in industrial production. At present, itaconic acid is mainly produced by submerged fermentation by Aspergillus terreus. A number of parameters have significant influence on the yield of itaconic acid, such as carbon source, nitrogen source, phosphate, metal ion, dissolved oxygen, pH, and temperature. The high cost of raw material is a crucial factor which impedes the expansion and development of the itaconic acid market in industrial production. Lignocellulose is a widely available and a promising low-cost substrate. The research of lignocellulosic hydrolysate as a substitute carbon source to produce itaconic acid is expected to reduce the production cost, which is of great significance to promote the development and application of itaconic acid.

Key words： Itaconic acid      Aspergillus terreus      Fermentation      Lignocellulose     
Received: 15 January 2021      Published: 01 June 2021
ZTFLH:  Q819  
Corresponding Authors: Feng-qin WANG     E-mail: w_fengqin@163.com
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Yin-ling GAO
Feng-jiao ZHANG
Gui-zhong ZHAO
Hong-sen ZHANG
Feng-qin WANG
An-dong SONG
Cite this article:

GAO Yin-ling,ZHANG Feng-jiao,ZHAO Gui-zhong,ZHANG Hong-sen,WANG Feng-qin,SONG An-dong. Research Progress of Itaconic Acid Fermentation. China Biotechnology, 2021, 41(5): 105-113.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2101019     OR     https://manu60.magtech.com.cn/biotech/Y2021/V41/I5/105

Microorganism Substrate Production
/(g/L)		 Yield
/(g/g)		 Productivity
/[g/(L·h)]		 System Ref.
A. terreus NRRL 1960 glucose 130 - - BF [2]
glucose 73.6 - - BF [25]
xylose 53.97 0.63 - BF [26]
A. terreus NRRL 1962 glucose 43.5 - 0.26 SF [27]
xylose 31.6 - 0.19
arabinose 16.7 - 0.10
A. terreus DSM 23081 glucose 92.4 0.53 - SF [28]
86.5 0.54 0.62 BF
glucose 129 0.58 1.15 BF [11]
glucose 160 0.46 0.99 BF [9]
A. terreus NRRL 1971 glucose 42.6 - - SF [29]
xylose 30.5 -
mannose 36.4 0.41 -
arabinose 25.8 - -
A. terreus CECT 20365 glucose 30.2 - - SF [30]
glycerol 26.9 - -
A. terreus MJL05 glycerol 27.6 0.44 0.192 BF [31]
U. maydis MB 215 glucose 220 0.45 0.73 BF [14]
U. vetiveriae TZ1 glycerol 34.7 0.18 0.09 SF [32]
Candidia sp. B-1 glucose 35 0.35 - SF [18]
A. niger glucose 26.2 - 0.35 BF [33]
E. coli glucose 4.34 - - BF [20]
E. coli glucose 2.27 0.77 - SF [34]
32 0.68 - BF
Yarrowia lipolytica glucose 4.6 0.058 0.045 BF [23]
Corynebacterium glutamicum glucose 7.8 0.4 0.002 1 SF [35]
Table 1 The itaconic acid yields in some strains has been reported
Fig.1 Simplified itaconic acid metabolic pathways of Ustilago maydis (a) and Aspergillus terreus (b) EMP: Embden-Meyerhof-Parnas; mtt: Mitochondrial TCA transporter; Adi1: Aconitate-Δ-isomerase; Tad1: trans-aconitate decarboxylase; Itp1: Itaconate transporter protein; CAD: cis-aconitate decarboxylase; mfs: Major facilitator superfamily protein
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[13] Ya-chao FAN,Lin ZHANG,Xiao-shu LI,Peng-xiang WANG,Xin-wu YAO,Kai QIAO. Study on the Fermentation of 2,3-Butanediol by Klebsiella pneumoniae CICC10011[J]. China Biotechnology, 2018, 38(2): 68-74.
[14] Li-na CHENG,Hai-yan LU,Shu-ling QU,Yi-qun ZHANG,Juan-juan DING,Shao-lan ZOU. Production of Cyclic Adenosine Monophosphate (cAMP) by Microbial Fermentation——A Review[J]. China Biotechnology, 2018, 38(2): 102-108.
[15] ZHANG Ling,WANG Nan,JIN Lv-hua,LIN Rong,YANG Hai-lin. To Promote the Expression of Leucine Dehydrogenase in Bacillus subtilis via Dual-Promoter and Fermentation Research[J]. China Biotechnology, 2018, 38(12): 21-31.
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