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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (8): 92-99    DOI: 10.13523/j.cb.20180812
综述     
细菌细胞壁生长调控机制研究进展 *
赵悦1,吴昊1,乔建军1,2,**()
1. 天津大学化工学院 系统生物工程教育部重点实验室 天津 300072
2. 天津大学化学化工协同创新中心合成生物学平台 天津 300072
Research on the Regulatory Mechanisms of Bacterial Cell Wall Growth
Yue ZHAO1,Hao WU1,Jian-jun QIAO1,2,**()
1. School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China
2. Syn Bio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China
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摘要：

在细菌生长过程中,细胞壁起到维持细胞形状和完整性,抵抗内部膨胀压的作用。细胞壁的合成、分裂、再生、循环再利用等与细菌自身生长繁殖和应对环境压力息息相关。目前,细胞壁生长机理,细菌如何调控细胞壁生长及如何与其他细胞过程相协调的机制尚未研究清楚。细胞壁调控机制的解析对了解细菌细胞壁功能、确定药物的作用方式和发展新一代的治疗方法至关重要。对细菌调控细胞壁生长机制的国外研究进展进行了概述,重点阐述了支架蛋白、转录因子、非编码小RNA及蛋白相互作用调控细胞壁的合成、细胞分裂、压力响应的机制,总结了细胞壁调控机制在抗菌药物研发中的应用,并对未来的研究方向进行了展望。
关键词： 细胞壁;  支架蛋白;  转录因子;  小RNA;  蛋白相互作用    
Abstract:

Cell wall can maintain the shape and integrity of cell and resist internal expansion pressure during bacterial growth.The synthesis, division, regeneration, and recycling of cell wall are closely related to bacterial growth and the response to environmental stress. At present, the mechanism of cell wall growth, how to regulate cell wall growth and how to coordinate with other cellular processes remain largely unknown.The regulation mechanism of cell wall is very important for understanding the function of bacterial cell wall, determining the action of new drugs and developing the new generation of treatment methods. In this review, the bacterial regulatory mechanism of cell wall growth is summerized and the mechanisms of the scaffolding proteins, transcriptional regulators as well as small non-coding RNA and the protein-protein interaction to control the synthesis of cell wall, cell division and stress response are highlighted. In addition, the application of cell wall regulatory mechanism in the development of antibacterial drugs is summed up, and the future research direction is proposed.
Key words: Cell wall    Scaffolding proteins    Regulator    sRNA    Protein-protein interaction
收稿日期: 2018-04-13 出版日期: 2018-09-11
ZTFLH:  Q935  
基金资助: 国家自然科学基金(31570089);国家自然科学基金(31170076)
通讯作者: 乔建军     E-mail: jianjunq@tju.edu.cn
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引用本文:

赵悦,吴昊,乔建军. 细菌细胞壁生长调控机制研究进展 *[J]. 中国生物工程杂志, 2018, 38(8): 92-99.

Yue ZHAO,Hao WU,Jian-jun QIAO. Research on the Regulatory Mechanisms of Bacterial Cell Wall Growth. China Biotechnology, 2018, 38(8): 92-99.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180812    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I8/92

图1  细菌细胞壁生长调控机制
图2  支架蛋白组成的肽聚糖合成复合物
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