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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (4): 90-95    DOI: 10.13523/j.cb.20180412
综述     
转录因子KLF8基因结构及其功能研究进展
徐嘉威1,贺花2,张静1,雷初朝1,陈宏1,黄永震1()
1 西北农林科技大学动物科技学院 杨陵 712100
2 西北农林科技大学动物医学学院 杨陵 712100
Research Progress on the Structure and Function of Transcription Factor KLF8 Gene
Jia-wei XU1,Hua HE2,Jing ZHANG1,Chu-chao LEI1,Hong CHENG1,Yong-zhen HUANG1()
1 College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China
2 College of Animal Medicine, Northwest Agriculture and Forestry University, Yangling　712100, China
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摘要：

随着分子生物学研究的进展,机体各种生物学特性的影响都在分子水平上寻求到原因。转录因子作为调节基因转录的重要蛋白质,一直在被人们进行种类发掘及功能鉴定。KLF8(Krüppel-like factor 8)是属于KLFs(Krüppel-like factors)家族中的一种转录因子,对细胞侵袭和上皮-间质转化、细胞致癌性转化和肿瘤、细胞周期循环、脂肪细胞分化等方面有着深远影响。由于其在生物学功能上的多方面影响,使其逐渐成为科研人员探究的热点。对该转录因子的结构和作用已经有了深入的了解。现就KLF8基因与蛋白质的分子结构和生物学特性研究进展进行综述,可为该基因作为遗传标记奠定基础并以期为相关研究如癌症调控、肥胖治疗及基础研究等提供参考。
关键词： KLF8基因;  转录因子;  结构特征;  生物学功能    
Abstract:

With the progress of molecular biology research, the influence of various biological characteristics of the organism seeks the reason at the molecular level. Transcription factors as the important protein regulate gene transcription, and they have been explore the types and functional identification. KLF8 (Krüppel-like factor 8) is a transcription factor belonging to the family of Krüppel-like factors (KLFs), which plays a significant role in cell invasion and epithelial-mesenchymal transition, cell carcinogenesis and tumor, cell cycle and adiposity differentiation. Due to its various biological functions, it gradually becomes a hot spot for researchers to explore. The structure and function of this transcription factor has been well understood. The research progress on the molecular structure and biological characteristics of KLF8 gene and protein are explained. The gene can be used as a genetic marker and provide a reference for related research such as cancer regulation, obesity treatment and basic research.
Key words: KLF8 gene    Transcription factor    Structural characteristics    Biological function
收稿日期: 2017-10-03 出版日期: 2018-05-08
ZTFLH:  Q78  
基金资助: 国家自然科学基金青年科学基金项目(31601926);中国博士后科学基金面上项目(2015M570856);陕西省自然科学基础研究计划面上项目(2017JM3024);国家肉牛牦牛产业技术体系专项资助项目(CARS-37)
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徐嘉威
贺花
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雷初朝
陈宏
黄永震

引用本文:

徐嘉威,贺花,张静,雷初朝,陈宏,黄永震. 转录因子KLF8基因结构及其功能研究进展[J]. 中国生物工程杂志, 2018, 38(4): 90-95.

Jia-wei XU,Hua HE,Jing ZHANG,Chu-chao LEI,Hong CHENG,Yong-zhen HUANG. Research Progress on the Structure and Function of Transcription Factor KLF8 Gene. China Biotechnology, 2018, 38(4): 90-95.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180412    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I4/90

图1  KLF8蛋白分子线性结构示意图
图2  KLF8在细胞周期中作用示意图
图3  KLF8依靠两种途径参与EMT发生
图4  KLF8参与脂肪细胞分化
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