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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (6): 70-76    DOI: 10.13523/j.cb.20180610
综述     
FoxO1在胰岛β细胞代谢灵活性受损及失代偿进程中的作用 *
冯琳晶1,于洋1,杜红伟1,2,**()
1 吉林大学基础医学院 长春 130021
2 吉林大学第一医院 长春 130021
The Role of FoxO1 in the Impaired Metabolic Flexibility and Decompensation Progress of Pancreatic Beta Cell
Lin-jing FENG1,Yang YV1,Hong-wei DU1,2,**()
1 School of Basic Medical Sciences, Jilin University, Changchun 130021, China
2 The First Hospital of Jilin University, Changchun 130021, China
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摘要：

葡萄糖及脂肪酸是胰岛β细胞的关键代谢底物,葡萄糖刺激胰岛β细胞分泌胰岛素是维持机体血糖稳态平衡的关键。胰岛素抵抗发生时,β细胞对能量代谢底物的选择失调,加速胰岛β细胞由代偿到胰岛β细胞失代偿的进程,是肥胖胰岛素抵抗最终发展为2型糖尿病的始动因素。核转录因子FoxO1属于Fox家族成员,在胰腺内广泛表达,在β细胞的代谢,发育,增殖过程中发挥着重要的调节作用。鉴于FoxO1在维持胰岛β细胞功能中的关键作用,现着重对FoxO1在胰岛β细胞代谢灵活性受损及失代偿过程发生中的作用调节进行阐述。为其作为调控胰岛β细胞功能的关键靶点提供参考。
关键词： 胰岛β细胞;  FoxO1;  代谢灵活性;  失代偿;  肥胖;  2型糖尿病    
Abstract:

It is well known that glucose and fatty acids are key metabolic substrates for pancreatic β-cells. Pancreatic β-cells secrete insulin by glucose stimulating to keep blood glucose levels within a homeostatic range. When insulin resistance occurs, β-cells metabolic flexibility has become the first victim of pancreatic β-cells dysfunction. Compensation to decompensation of pancreatic β-cells is the key for the development of obesity insulin resistance to type 2 diabetes. Nuclear transcription factor FoxO1 (forkhead box O1) belongs to the Fox family, which is widely expressed in pancreatic β-cells. FoxO1 is a key regulator of the insulin-signaling pathway, and is reported to play important roles in pancreatic β-cells differentiation, proliferation, apoptosis and stress resistance. In view of the key role of FoxO1 in the maintenance of pancreatic β-cells function, an overview focused on the role of FoxO1 in the impaired metabolic flexibility and decompensation progress of pancreatic beta cells is provided.
Key words: Pancreatic β-cells    FoxO1    Metabolic flexibility    Decompensation    Obesity    T2DM
收稿日期: 2018-01-03 出版日期: 2018-07-06
ZTFLH:  R967  
基金资助: * 国家自然科学基金(81503122);吉林省科技发展计划基础研究计划自然科学基金资助项目(20150101156JC)
通讯作者: 杜红伟     E-mail: dhw_101@126.com
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引用本文:

冯琳晶,于洋,杜红伟. FoxO1在胰岛β细胞代谢灵活性受损及失代偿进程中的作用 *[J]. 中国生物工程杂志, 2018, 38(6): 70-76.

Lin-jing FENG,Yang YV,Hong-wei DU. The Role of FoxO1 in the Impaired Metabolic Flexibility and Decompensation Progress of Pancreatic Beta Cell. China Biotechnology, 2018, 38(6): 70-76.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180610    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I6/70

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