| 综述 |
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| 杂合抗菌肽设计及生物学活性的研究进展 |
| 武如娟, 张日俊 |
| 中国农业大学动物科技学院 动物营养学国家重点实验室 北京 100193 |
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| The Progress of Hybrid Peptides on Design and Biological Activity |
| WU Ru-juan, ZHANG Ri-jun |
| State Key Laboratory for Animal Nutrition, College of Animal Science and Technology, China Agriculture University, Beijing 100193, China |
[1] 王兴顺,耿艺介,李文楚. 抗菌肽抗菌机制及其应用研究进展. 微生物学免疫学进展,2012, 40 (4): 70-75. Wang X SH, Geng Y J, Li W CH. The progress of mechanism and application for antibacterial peptides Progress of Microbial Immunology, 2012, 40 (4): 70-75.
[2] Reddy K V R, Yedery R D, Aranha C. Antimicrobial peptides: premises and promises. Int J Antimicrob Agents, 2004, 24: 536-547.
[3] Boman H,Wade D, Boman A, et a1.Antibacterial and antimicrobial properties of peptides that are cecropin2-melittin hybrids.FEBS Lett, 1989, 259 (1): 103-106.
[4] Andrea G, Giovanna P, Silvia F N. Antimicrobial peptides: an overview of a promising class of therapeutics. Cent Eur J Biol, 2007, 2 (1): 1-33.
[5] 李趣欢, 张文军. 两亲A-螺旋抗菌肽的分子设计研究现状与进展.中国新药杂志, 2005, 14 (9): 1126-1133. Li Q H, Zhang W J. The present station and advance of amphipathicity AMPs on molecular design.Journal of China New Medicine, 2005, 14 (9): 1126-1133.
[6] 王秀青,朱明星,张爱君, 等.天蚕素类杂合肽cecropinA-magajnin突变体的合成以及在毕赤酵母中的分泌表达.东北农业大学学报, 2009, 40 (11):95-98. Wang X Q, Zhu M X, Zhang A J, et al. Design and expression of hybrid peptide cecropinA-magajnin in Pichia pastoris. Academic Journal of Northeast Agricultural University, 2009, 40 (11): 95-98.
[7] Yeaman M R, Yount N Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev, 2003, 55 (1): 27-55.
[8] Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res, 2000, 1 (3): 141-150.
[9] Lemaitre B, Reichhart J M, Hoffmann J A. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA, 1997, 94 (26): 14614-14619.
[10] Syma K, Peter J. B. Multiscale molecular dynamics simulations of membrane proteins. Biomolecular simulations: Methods and Protocols. Methods in Molecular Biology, 2013, 924:635-637.
[11] Chen H C, Brown J H, Morell J L, et al. Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett, 1988, 236: 462-466.
[12] Ohsaki Y, Gazdar A F, Chen H C, et al. Antitumor activity of magainin analogues against human lung cancer cell lines. Cancer Res, 1992, 52:3534-3538.
[13] Hancock R E. Cationic peptides:efectors in innate immunity and novel antimicrobials. Lancet Infect Dis, 2001, 1 (3):156-164.
[14] Dathe M, Nikolenko H, Meyer J, et al. Optimization of the antimicrobial activity of magainin peptides by modification of charge. FEBS Lett, 2001, 501: 146-150.
[15] 宋雪莹,冯兴军,李静. 抗菌肽分子设计研究进展. 饲料博览, 2010, 9: 13-15. Song X Y, Feng X J, Li J. The advance of AMPS on molecular design. Feed Expo, 2010, 9: 13-15.
[16] Lee D G, KimH N, Park Y, et al. Design ofnovel analogue peptides with potent antibiotic activity based on the antimicrobial peptide,HP(2-20), derivedfrom N-terminus of Helicobacter pylori ribosomal protein L1.Biochem Aiophys Acta, 2002, 1598 (1,2):185-194.
[17] Christopher E D, Ayman H, Robin A H, et al. Origin of lowmammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. J Bio Chem, 2008, (4):1-20.
[18] Uematsu N, Matsuzaki K. Polar angle as a determinant of amphipathic alpha-helix-lipid interactions: a model peptide study. Biophys J, 2000, 79: 2075-2083.
[19] Matsuzaki K, Harada M, Funakoshi S, et al. Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayers. Biochim Biophys Acta, 1991, 1063:162-170.
[20] Matsuzaki K, Mitani Y, Akada K Y, et al. Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa. Biochemistry, 1998, 37: 15144-15153.
[21] 刘琳,马廷方,祝永强,等. 抗菌肽的结构特征及其与活性的关系. 药物生物技术, 2008, 15(1):64-67. Liu L, Ma T F, Zhu Y Q, et al. The structural character of AMPs and the relationship between structure and activity. Pharmaceutical Biotechnology, 2008, 15 (1): 64-67.
[22] Shin S Y, Kang S W, Lee D G, et al. CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity. Biochem Biophys Res Commun, 2000, 275: 904-909.
[23] Shin, S. Y, Rang, J. H, Hahm, K S. Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptides. J Pept Res, 1999, 53: 82-90.
[24] Lee K, Shin S Y, Kim K, et al. Antibiotic activity and structural analysis of the scorpion derived antimicrobial peptide IsCT and its analogs. Biochem Bioph Res Co, 2004, 323 (2):712-719.
[25] Jaynes J M.Use of genes encoding novel lytic peptides and proteins that enhance microbial disease esistance in plants.Acta Hortic,2007, 336: 33-39.
[26] Boman H G,Hultmark D.Cell free immunity in insects.Ann Rev Microbiol,1987,41:103-126.
[27] Wade D, Andreu D. Antibacterial peptides designed as analogs or hybrids of cecropins andmelittin. Int J Pept Protein Res, 1992, 40 (5): 429-436.
[28] Andreu D, Ubach J, Boman A, et al. Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. FEBS Lett, 2002, 24: 347-353.
[29] Shin S Y, Lee M K, Kim k l, et al. Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides. J Pept Res, 1997, 50: 279-185.
[30] Strom M B,Hang B E,Rekdal O,et al.Important structural features of 15-residue lactoferricin derivatives and methods for improvements of antimicmbial activity. Biochem Cell Biol,2002,80 (1):65-74.
[31] 冯兴军,李静,赵晓宇, 等,牛乳铁蛋白素-马盖宁杂合抗菌肽的设计、合成及抑菌活性.东北农业大学学报, 2011, 42 (3):105-109. Feng X J, Li J, Zhao X Y, et al. Design, synthesis, antibacterial activity of bovine lactoferrin-maganine hybrid peptide. Academic Journal of Northeast Agricultural University, 2011, 42 (3): 105-109.
[32] Strom M B,Hang B E,Rekdal O,et al.Important structural features of 15-residue lactoferricin derivatives and methods for improvements of antimicmbial activity.Biochem Cell Biol,2002,80 (1):65-74.
[33] Daher, K A, Selsted, M E. Lehrer R I. Direct inactivation of viruses by human granulocyte defensins, Am Soc Microbiol, 1986, 60: 1068-1074.
[34] Wachinger M, Kleinschmidt A, Winder D, et al. Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression. J Gene Virol, 1998, 79: 731-740.
[35] Andersen, J H, Jenssen H. Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparin sulphate at the cell surface. J Med Syst, 2004, 74 (2): 262-271.
[37] Baker M A, Maloy W L, Zasloff M, et al. Anticancer efficacy of magainin 2 and analogue peptides. Cancer Res, 1993, 53:3052-3057.
[38] Soballe P W, Maloy W L, Myrga M L, et al. Experimental local therapy of human melanoma with lytic magainin peptides. Int J Cancer, 1995, 60:280-284.
[39] Lehmann J, Retz M, Sidhu S S, et al. Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines. Eur Urol, 2006, 50:141-147.
[40] Moore A J, Devine D A, Bibby M C. Preliminary experimental anticancer activity of cecropins. Pept Res, 1994, 7:265-269.
[41] Yoo Y C, Watanabe S, Watanabe R, et al. Bovine lactoferrin and lactoferricin inhibit tumor metastasis in mice. Adv Exp Med Biol, 1998, 443:285-291.
[42] Mader J S, Salsman J, Conrad D M, et al. Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther, 2005, 4:612-624.
[43] Eliassen LT, Berge G, Leknessund A, et al. The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo. Int J Cancer, 2006, 119:493-500.
[44] Eliassen LT, Berge G, Sveinbjornsson B, et al. Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Res, 2002, 22: 2703-2710.
[45] Bateman A, Singh A, Jothy S, et al. The levels and biologic action of the human neutrophil granule peptide HP-1 in lung tumors. Peptides, 1992, 13:133-139.
[46] Mizukawa N, Sugiyama K, Kamio M, et al. Immunohistochemical staining of human alpha-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas. Anticancer Res, 2000, 20:1125-1127.
[47] Muller C A, Markovic-Lipkovski J, Klatt T, et al. Human alpha-defensins HNPs-1,-2, and-3 in renal cell carcinoma influences on tumor cell proliferation. Am J Pathol, 2002, 160:1311-1324.
[48] Holterman D A, Diaz J I, Blackmore P F, et al. Overexpression of alpha-defensin is associated with bladder cancer invasiveness. Urol Oncol, 2006, 24:97-108.
[49] Hancock R E W, Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol, 2000, 8:402-410.
[50] Ganz T, Metcalf J A, Gallin J I, et al. Microbicidal/ cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and 'specific’ granule deficiency. J Clin Invest, 1988, 82:552-556.
[51] Putsep K, Carlsson G, Boman H G, et al. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet, 2002, 360:1144-1149.
[52] Ong P Y, Ohtake T, Brandt C, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med, 2002, 347:1151-1160.
[53] Nomura I, Goleva E, Howell M D, et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol, 2003, 171:3262-3269.
[54] Moser C, Weiner D J, Lysenko E, et al. β-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun 2002, 70:3068-3072.
[55] Rosenberger C M, Gallo R L, Finlay B B. Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication. Proc Natl Acad Sci USA, 2004, 101:2422-2427.
[56] Iimura M, Gallo R L, Hase K, et al. Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J Immunol, 2005, 174:4901-4907.
[57] Nizet V, Ohtake T, Lauth X, et al, Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature, 2001, 414:454-457.
[58] Salzman N H, Ghosh D, Huttner K M, et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature, 2003, 422:522-526. |
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