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[1] Pelham H R. A regulatory upstream promoter element in the Drosophila hsp 70 heat-shock gene. Cell, 1982,30(2):517-528.

[2] Joshi B, Ordonez-Ercan D, Dasgupta P,et al. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene,2005,24(13):2204-2217.

[3] Nikolic D B, Samardzic J T, Bratic A M, et al. Buckwheat (Fagopyrum esculentum Moench) FeMT3 gene in heavy metal stress: protective role of the protein and inducibility of the promoter region under Cu(2+) and Cd(2+) treatments. J Agric Food Chem, 2010,24;58(6):3488-3494.

[4] McTavish N, Getty J, Burchell A, et al. Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1. Biochem J, 2009, 25;423(2):189-197.

[5] Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A, 1992, 89(12):5547-5551.

[6] Gossen M, Freundlieb S, Bender G, et al. Transcriptional activation by tetracyclines in mammalian cells. Science, 1995,268(5218):1766-1769.

[7] Schultze N, Burki Y, Lang Y, et al. Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nat Biotechnol, 1996, 14(4):499-503.

[8] Soulier S, Stinnakre M G, Lepourry L, et al. Use of doxycycline-controlled gene expression to reversibly alter milk-protein composition in transgenic mice. Eur J Biochem, 1999,260(2):533-539.

[9] Kistner A, Gossen M, Zimmermann F, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A, 1996,93(20):10933-10938.

[10] Diamond I, Owolabi T, Marco M, et al. Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol, 2000,115(5):788-794.

[11] Wang H, Chae K R, Shin D H, et al. Xenobiotic response in humanized double transgenic mice expressing tetracycline-controlled transactivator and human CYP1B1. Arch Biochem Biophys, 2001,395(1):32-40.

[12] Boy J, Leergaard T B, Schmidt T, et al. Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models. Neuroimage, 2006,33(2):449-462.

[13] Zhou H, Huang C, Yang M, et al. Developing tTA transgenic rats for inducible and reversible gene expression. Int J Biol Sci, 2009,5(2):171-181.

[14] Odeh F, Leergaard T B, Boy J, et al. Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brain. NeuroImage, 2011,2603-2611.

[15] Perl A K, Tichelaar J W, Whitsett J A. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res, 2002,11(1):21-29.

[16] Zhu Z, Zheng T, Lee C G, et al. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol, 2002,13(2):121-128.

[17] Shigehara T, Zaragoza C, Kitiyakara C, et al. Inducible podocyte-specific gene expression in transgenic mice. J Am Soc Nephrol, 2003,14(8):1998-2003.

[18] Gallagher A R, Schnig K, Brown N, et al. Use of the tetracycline system for inducible protein synthesis in the kidney. J Am Soc Nephrol, 2003, 14(8):2042-2051.

[19] Grill M A, Bales M A, Fought A N, et al. Tetracycline-inducible system for regulation of skeletal muscle-specific gene expression in transgenic mice. Transgenic Res, 2003, 12(1):33-43.

[20] Hayashi M, Hayashi Y, Liu C Y, et al. Over expression of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of Kerapr-rtTA/FGF7 bitransgenic mice. Mol Vis, 2005,11:201-207.

[21] Dumortier J, Schnig K, Oberwinkler H, et al. Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice. Gene Ther, 2005,12(8):668-677.

[22] Shen Q, Sun Q, Wei X, et al.Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. J Biosci Bioeng, 2007, 104(1):14-21.

[23] Song X, Guo Y, Duo S, et al. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol, 2009,175(5):1975-1983.

[24] Zhou H, Liu Y, He F, et al. Temporally and spatially controllable gene expression and knockout in mouse urothelium. Am J Physiol Renal Physiol, 2010,299(2):F387-F395.

[25] Sheng Y, Lin C C, Yue J, et al. Generation and characterization of a Tet-On(rtTA-M2) transgenic rat. BMC Developmental Biology, 2010, 10:17.

[26] Zhu Z, Ma B, Homer R J, et al. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem, 2001,276(27):25222-25229.

[27] Uchida S, Sakai S, Furuichi T, et al. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes Brain Behav, 2006,5(1):96-106.

[28] Hayakawa T, Yusa K, Kouno M, et al. Blooms syndrome genedeficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Gene, 2006, 369:80-89.

[29] Yusa K, Horie K, Kondoh G, et al. Genome-wide phenotype analysis in ES cells by regulated disruption of Blooms syndrome gene. Nature,2004, 429(6994):896-899.