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中国生物工程杂志

China Biotechnology
China Biotechnology  2012, Vol. 32 Issue (04): 103-109    DOI:
    
Natural Product Glycosylation and Aglycone Diversifcation
LIU Jun, CHEN Ming
State Key Laboratory of Microbial Technology, Jinan 250100, China) (National Glycoengineering Research Center, Jinan 250100, China
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Abstract  

The bioactivity of many natural products including antibiotics and anticancer therapeutics depends on their sugar moieties. Changes in the structures of these sugars can deeply influence the biological activity, specificity and pharmacological properties of the parent compounds. A unique characteristic of sugar moieties is their structural diversity which is greater than that of many other biological compounds. Modification of these parts has become an important strategy to achieve many clinical drug candidates. Research groups have focused upon the development of chemical and enzymatic tools to diversity natural product glycosylation.The glycosylation process of natural products and four strategy to diversity glycosylation were discussed in detail.



Key wordsGlycosylation of natural products      Diversity of glycosylation      Combinatorial biology      Glycosyltranferase     
Received: 10 November 2011      Published: 25 April 2012
ZTFLH:  Q819  
Cite this article:

LIU Jun, CHEN Ming. Natural Product Glycosylation and Aglycone Diversifcation. China Biotechnology, 2012, 32(04): 103-109.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2012/V32/I04/103


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