中国生物工程杂志

［1］ Narita N, Nishio H, Kitoh Y, et al. Insertion of a 5'truncated L1 element into the 3' end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy.J Clin Invest, 1993, 91:18621867. 
［2］ Bailey J A, Carrel L, Chakravarti A, et al. Molecular evidence for a relationship between LINE1 elements and X chromosome inactivation: the Lyon repeat hypothesis.Proc Natl Acad Sci USA, 2000, 97:66346639. 
［3］ Allen E, Horvath S, Tong F, et al. High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.Proc Natl Acad Sci USA, 2003, 100:99409945. 
［4］ Burwinkel B, Kilimann M W. Unequal homologous recombination between LINE1 elements as a mutational mechanism in human genetic disease.J Mol Biol, 1998, 277:513517. 
［5］ Liu L, Chen X H, Huang J, et al. NSSR1 promotes neuronal differentiation of mouse embryonic carcinoma P19 cells. Neuroreport, 2004, 15:823828. 
［6］ Anthony V Furano1, David D Duvernell， Stephane Boissinot. L1 (LINE1) retrotransposon diversity differs dramatically between mammals and fish.Trends in Genetics,2004 ,20 (1):914. 
［7］ Xi Shi, Andrei Seluanov, Vera Gorbunova.Cell divisions are required for L1 retrotransposition.Molecular and Cellular Biology,2007, 27（4 ）：12641270. 
［8］ RomanGomez J, JimenezVelasco A, Agirre X, et al. Promoter hypomethylation of the LINE1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia.Oncogene,2005,24:72137223. 
［9］ Goodier J L, Zhang L, Vetter M R, et al. LINE1 ORF1 protein localizes in stress granules with other RNAbinding proteins, including components of RNA interference RNAinduced silencing complex. Mol Cell Biol,2007，27:64696483. 
［10］ Wichai Pornthanakasem, Narisorn Kongruttanachok， Chutipa Phuangphairoj. LINE1 methylation status of endogenous DNA doublestrand breaks..Nucleic Acids Research, 2008, 6（11）:36673675. 
［11］ Marcos R H, Este′ciol Vazganush Gharibyanl, Lanlan Shen1.LINE1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE, 2007，2(5): e399. 
［12］ Gasior S L, Wakeman T P, Xu B,et al. The human LINE1 retrotransposon creates DNA doublestrand breaks.J Mol Biol, 2006，357:13831393. 
［13］ Martin S L, Cruceanu M, Branciforte D, et al. LINE1 retrotransposition requires thenucleic acid chaperone activity of the ORF1 protein.J Mol Biol, 2005,348(3):549561. 
［14］ Morrish T A, Gilbert N, Myers J S, et al. DNA repair mediated by endonuclease independent LINE1 retrotransposition.Nat Genet,2002,31 (2):159165. 
［15］ Piskareva O, Schmatchenko V. DNA polymerization by the reverse transcriptase of the human L1 retrotransposon on its own template in vitro. FEBS Lett, 2006,580:661668. 
［16］ Yang N, Zhang L, Kazazian H H. L1 retrotransposonmediated stable gene silencing.Nucleic Acids Res,2005,33(6):e57. 
［17］ Morello K C, Wurz G T, DeGregorio M W. SERMs: current status and future trends . Critical Reviews in Oncology/ Hematology , 2002 , 43 (1) : 63  76. 
［18］ Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage.Science, 1998, 282 (5393) : 1497  1501. 
［19］ Scott M T, Morrice N, Ball K L. Reversible phosphorylation at the Cterminal regulatory domain of p21 (Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J Biol Chem, 2000,275(15): 11529  11537.