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中国生物工程杂志

China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (9): 102-107    DOI: 10.13523/j.cb.20140915
    
Progress on the Inhibition of Hepatitis B virus by siRNA Strategy
SU Lan, ZHANG Ping, WANGYANG Jun-qi, ZHONG Ru-gang
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China;
Beijing Key Laboratory of Environmental and Viral Oncology, Beijing 100124, China
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Abstract  

Hepatitis B is one of the highest incidence and mortality diseases and caused mainly by the acute and chronic infection of hepatitis B virus (HBV). Nowadays, the treatments of HBV-infected patients are mainly dependent on the antiviral drugs, such as nucleotide analogues and interferon. However, analysis of viral kinetics during therapy revealed that the virus replication was not completely inhibited and the rate of clearance of infected hepatocytes was slow during therapy. Recently, large amount of experiments showed that RNA interference (RNAi) were capable of reducing HBV gene expression and replication in vivo when HBV genes were delivered simultaneously with small interfering RNA (siRNA) or siRNA expression constructs. RNAi-based therapeutics has the potential to treat chronic HBV infection in a fundamentally different manner than current therapies. The main target HBV gene to be silenced, siRNA delivery strategy, the therapy efficiency and the application prospects have been discussed in this review.



Key wordsHepatitis B Virus      RNA interference      Small interfering RNA     
Received: 27 May 2014      Published: 25 September 2014
ZTFLH:  Q522  
Cite this article:

SU Lan, ZHANG Ping, WANGYANG Jun-qi, ZHONG Ru-gang. Progress on the Inhibition of Hepatitis B virus by siRNA Strategy. China Biotechnology, 2014, 34(9): 102-107.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20140915     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I9/102


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