精原干细胞具有自我复制和分化成精子的能力，是动物体内唯一能进行遗传信息传递的干细胞。因此，精原干细胞既是干细胞生物学的重要研究对象，又是研究精子发生、制作转基因动物和研究基因功能的重要资源。本文报道了精原干细胞体外培养的研究历史和最新进展，并对精原干细胞体外培养的影响因素和自我增殖的维持机制等作了综述。
Spermatogonial stem cells (SSCs)，the only stem cells that are capable of transmitting genetic information to subsequent generations in adult animals，have abilities to self-renew and differentiate into spermatozoa. Therefore, SSCs are not only the study object of stem cell biology, but also the valuable resource of in vitro spermatogenesis, gene analysis and functional genomics. The present paper reported the study history and recent progress of in vitro culture for SSCs, and summarized the influence factors of SSC in vitro culture and maintenance mechanisms of SSC self-renewal.
王庆忠. 精原干细胞体外培养的研究进展[J]. 中国生物工程杂志, 2008, 28(专刊): 220-225.
Wang Qingzhong. Research progress on the in vitro culture of spermatogonial stem cells. China Biotechnology, 2008, 28(专刊): 220-225.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2008/V28/I专刊/220
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