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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2024, Vol. 44 Issue (1): 107-117    DOI: 10.13523/j.cb.2306041
综述     
噬菌体与细菌基于群体感应的双向互作*
孙舒扬1,吴胜波1,2,张欣乔1,梁畅畅1,乔建军1,2,3,4,***()
1 天津大学化工学院 天津 300072
2 天津大学浙江研究院(绍兴) 绍兴 312300
3 天津大学系统生物工程教育部重点实验室 天津 300072
4 天津化学化工协同创新中心合成生物学平台 天津 300072
Advances in Quorum-sensing Bidirectional Interactions Between Phages and Bacteria
Shuyang SUN1,Shengbo WU1,2,Xinqiao ZHANG1,Changchang LIANG1,Jianjun QIAO1,2,3,4,***()
1 School of Chemical Engineering, Tianjin University, Tianjin 300072, China
2 Zhejiang Institute of Tianjin University (Shaoxing), Shaoxing 312300, China
3 Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China
4 Synthetic Biology Research Platform, Tianjin Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China
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摘要：

在长期的共同进化过程中,噬菌体与细菌宿主之间产生了复杂的相互作用关系。群体感应(quorum sensing,QS)机制在噬菌体和细菌的双向相互作用中扮演了重要角色。综述细菌宿主对群体感应机制的利用,群体感应对生物被膜调节、噬菌体吸附过程以及调控CRISPR-Cas系统等方面所起到的效果,从噬菌体对群体感应机制的介入,总结群体感应机制在噬菌体溶原-裂解性调节以及噬菌体对群体感应机制的抑制,探讨对噬菌体QS机制的挖掘和解析,以期为群体感应机制在噬菌体治疗等领域的应用提供理论依据。
关键词： 群体感应;  噬菌体-细菌宿主;  溶原-裂解;  微生物相互作用    
Abstract:

During the extensive co-evolutionary process, complex interactions have emerged between phages and bacterial hosts. Quorum sensing (QS) mechanisms play a prominent role in governing the interactions between phages and bacteria. This article begins by elucidating the exploitation of QS mechanisms by bacterial hosts, providing an overview of their consequential impacts on biofilm regulation, phage adsorption processes, and the modulation of the CRISPR-Cas system. Furthermore, the involvement of phages in QS mechanisms is expounded upon, encompassing a comprehensive survey of their role in phage lytic-lysogenic regulations and the suppression of QS mechanisms. Finally, this article presents a prospective investigation and explanation of phage QS mechanisms, aiming to provide a theoretical foundation for the application of QS mechanisms in the field of phage therapy and related areas.
Key words: Quorum sensing    Phage-bacterial host    Lysogen-lysis    Microbial interaction
收稿日期: 2023-07-02 出版日期: 2024-02-04
ZTFLH:  Q939.48  
基金资助: *中国博士后科学基金(2023M732599);国家重点研发计划(2019YFA0905600);中国创新研究群体基金(21621004)
通讯作者: *** 电子信箱:jianjunq@tju.edu.cn   
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引用本文:

孙舒扬, 吴胜波, 张欣乔, 梁畅畅, 乔建军. 噬菌体与细菌基于群体感应的双向互作*[J]. 中国生物工程杂志, 2024, 44(1): 107-117.

Shuyang SUN, Shengbo WU, Xinqiao ZHANG, Changchang LIANG, Jianjun QIAO. Advances in Quorum-sensing Bidirectional Interactions Between Phages and Bacteria. China Biotechnology, 2024, 44(1): 107-117.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2306041    或    https://manu60.magtech.com.cn/biotech/CN/Y2024/V44/I1/107

图1  细菌利用群体感应系统调控生物被膜形成[37]
图2  细菌利用群体感应系统调控噬菌体吸附位点
图3  细菌利用群体感应系统调控CRISPR-Cas系统
图4  噬菌体通过群体感应调控自身溶原-裂解过程
图5  噬菌体抑制细菌群体感应系统
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