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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2023, Vol. 43 Issue (2/3): 120-129    DOI: 10.13523/j.cb.2208024
综述     
巨噬细胞移动抑制因子调控细胞衰老的研究进展*
李玉锦1,王杰1,王亚妮2,汪耀2,孟佳敏2,张红兵2,**()
1 西北大学生命科学学院 西安 710069
2 西北大学附属第一医院 西安市第一医院 陕西省眼科研究所 西安 710002
Research Progress of Macrophage Migration Inhibitory Factor Regulating Cell Senescence
LI Yu-jin1,WANG Jie1,WANG Ya-ni2,WANG Yao2,MENG Jia-min2,ZHANG Hong-bing2,**()
1 College of Life Science, Northwest University, Xi’an 710069, China
2 The First Affiliated Hospital of Northwest University, Xi’an First Hospital, Eye Institute of Shaanxi Province, Xi’an 710002, China
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摘要：

巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)是一种可被多种细胞表达的多效性细胞因子,对细胞的多种生物学功能发挥调控作用,包括细胞的增殖、分化、存活和凋亡,近期研究发现MIF与细胞衰老相关。为了进一步认识衰老的机制,对MIF与细胞衰老相关的研究进展作了总结,重点分析了MIF调控细胞衰老的机制,MIF调控衰老相关基因表达的机制,尤其是在缺氧和氧化应激条件下MIF调控衰老的机制,并分析了在MIF功能多态性背景下其对衰老相关疾病的复杂调控机制,最后介绍了MIF及其受体的生物工程产品开发和应用,为进一步研究MIF调控细胞衰老的机制奠定基础。
关键词： 巨噬细胞移动抑制因子;  细胞衰老;  氧化应激    
Abstract:

Macrophage migration inhibitory factor (MIF) is a widely expressed pleiotropic cytokine that controls various biological functions of cells, including cell proliferation, differentiation, survival and apoptosis. Recent studies have found that MIF is closely associated with cell senescence, suggesting that MIF may regulate cell senescence. To further understand the mechanism of cell senescence, the role of MIF in cell senescence and its mechanism in recent studies was summarized in this article, which includes how MIF controls senescence related gene expression, especially in hypoxia and oxidative stress conditions. The complex regulatory mechanisms of aging related diseases in the context of MIF functional polymorphism were further analyzed. Finally, the development and application of bioengineering products of MIF and its receptors were introduced. It lays a foundation for further study on the mechanism of MIF regulating cell senescence.
Key words: Macrophage migration inhibitory factor (MIF)    Cell senescence    Oxidative stress
收稿日期: 2022-08-17 出版日期: 2023-03-31
ZTFLH:  Q819  
基金资助: *陕西省自然科学基础研究计划(2021JZ-60);陕西省自然科学基础研究计划面上项目(2021JM-593)
通讯作者: **张红兵     E-mail: zhanghongbing01@163.com
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李玉锦
王杰
王亚妮
汪耀
孟佳敏
张红兵

引用本文:

李玉锦, 王杰, 王亚妮, 汪耀, 孟佳敏, 张红兵. 巨噬细胞移动抑制因子调控细胞衰老的研究进展*[J]. 中国生物工程杂志, 2023, 43(2/3): 120-129.

LI Yu-jin, WANG Jie, WANG Ya-ni, WANG Yao, MENG Jia-min, ZHANG Hong-bing. Research Progress of Macrophage Migration Inhibitory Factor Regulating Cell Senescence. China Biotechnology, 2023, 43(2/3): 120-129.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2208024    或    https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I2/3/120

图1  MIF调控细胞周期的机制
图2  MIF调控细胞衰老的机制
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