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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2023, Vol. 43 Issue (2/3): 1-14    DOI: 10.13523/j.cb.2301001
新型药物递送系统研发与应用专题     
新型药物递送系统研发格局分析*
韩佳,张博文,毛开云**()
中国科学院上海营养与健康研究所 中国科学院上海生命科学信息中心 上海 200031
Analysis of R&D Structure of New Drug Delivery Systems
HAN Jia,ZHANG Bo-wen,MAO Kai-yun**()
Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031,China
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摘要:

药物递送是通过特定的手段使活性药物成分有效地递送到目的部位,以在人类或动物中实现治疗效果的方法或过程。递送系统在控速给药、靶向给药、药物稳定性、生物相容性等方面具有重要的作用。近年来,随着药学、材料学和生物医学等相关领域的进步,从纳米尺度、细胞尺度到智能靶向递送等技术的发展使药物递送系统领域发生了巨大变化,新型药物递送系统的研究投入和市场份额持续快速增长。通过对不同载药系统的递送机制及特点进行阐述,系统梳理新兴药物递送系统技术的主要研究进展及企业竞争格局,并对相关技术的临床转化潜力和应用前景进行展望,为相关企业研发方向选择及决策提供参考。

关键词: 药物递送系统药物制剂技术技术平台研发格局    
Abstract:

Drug delivery is a method or process for achieving therapeutic effects in humans or animals by using specific means to effectively deliver active pharmaceutical ingredients to target sites. The delivery systems play important roles in controlling the speed of drug release, targeting drug delivery to the site, maintaining drug stability and biocompatibility. In recent years, with the advancements of related fields such as pharmaceutical science, material science, and biomedicine, the development of technologies from nanoscale to cell scale and smart targeted drug delivery has brought tremendous changes in the field of drug delivery systems, The research investment and market share of drug delivery systems continue to grow rapidly. This paper elaborated the delivery mechanism and characteristics of different drug delivery systems, systematically analyzed the main research progresses and enterprise competition pattern of new drug delivery system technologies, and discussed the clinical transformation potential and application prospects of related technologies, in order to provide references for the choice of R&D direction selection and decision-making of related companies.

Key words: Drug delivery system    Pharmaceutical preparations technique    Technology platform    Current status of R & D
收稿日期: 2023-01-01 出版日期: 2023-03-31
ZTFLH:  Q819  
基金资助: *上海市2022年度“科技创新行动计划”软科学研究(22692116401)
通讯作者: **毛开云     E-mail: kymao@sinh.ac.cn
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引用本文:

韩佳, 张博文, 毛开云. 新型药物递送系统研发格局分析*[J]. 中国生物工程杂志, 2023, 43(2/3): 1-14.

HAN Jia, ZHANG Bo-wen, MAO Kai-yun. Analysis of R&D Structure of New Drug Delivery Systems. China Biotechnology, 2023, 43(2/3): 1-14.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2301001        https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I2/3/1

分类 关键细分技术
靶向递送技术
主动靶向递送技术
被动靶向递送技术
高分子聚合物递送技术 储层型高分子聚合物药物递送系统
整体型高分子聚合物药物递送系统
超支化高分子聚合物载药系统
乳化递送技术 脂质体递送技术
脂肪乳递送技术
纳米药物递送技术 超分子自主组装纳米递送体系
仿生纳米载体
金属和无机纳米粒子
眼科纳米递送系统
仿生型药物递送系统 细胞膜递送技术
仿病毒纳米颗粒
蛋白质或多肽递送技术 蛋白质-药物偶联物
多肽-药物偶联物
核酸药物递送技术 病毒载体
脂质体、聚合物纳米递送技术等
GalNAc递送系统
外泌体药物递送技术 工程化外泌体技术
外泌体模拟物技术
人造外泌体技术
智能可编程递送技术 温感药物递送体系
光控药物递送体系
磁控药物递送体系
超声控释递送体系
DNA折纸技术
部分透皮给药和植入给药装置
微针给药技术 微针技术
离子导入技术
促渗技术等
无针给药装置 大容量射流注射技术
蛋白质多肽类、基因药物无针给药技术
微输液植入装置 颅内给药装置
鞘内药物输注系统
活细胞递送系统 红细胞载药技术
血小板载药技术巨噬细胞载药技术
表1  新型药物递送系统关键技术梳理
图1  2021~2030年全球药物递送系统市场规模
代表性企业 代表性平台技术
国外 BD公司(Becton, Dickinson and Company) 微针给药技术、无针给药装置、微输液植入装置
Bluebird Bio蓝鸟生物 核酸药物递送
Arcturus Therapeutics大角星治疗 乳化递送技术、核酸药物递送
Micellae Delivery Systems米切拉公司 乳化递送技术
Souvie Biodelivery索维公司 外泌体药物递送技术
Carocell Bio卡罗赛尔生物 高分子聚合物递送技术
Sixfold Bioscience六重生物科学 智能可编程递送技术、核酸药物递送
Aqdot阿克多特 智能可编程递送技术、纳米药物递送技术
国内 斯微生物 核酸药物递送、靶向递送技术
艾博生物 核酸药物递送、乳化递送技术
康希诺生物 核酸药物递送、纳米药物递送技术
启辰生生物 核酸药物递送
嘉晨西海 核酸药物递送
表2  新型药物递送系统国内外代表性企业
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