中国生物工程杂志

In order to obtain a more ideal skin wound repair dressing, human hair keratin (KTN) is compounded on the basis of sodium alginate (SA) and polyacrylamide (PAM) hydrogel to prepare KTN/SA/PAM hydrogel glue skin dressing.It was characterized by an electronic universal testing machine, scanning electron microscope, etc. The results showed that the tensile strength of the KTN/SA/PAM hydrogel skin dressing was 42.41 kPa and the elastic modulus was 11.19 kPa, which were close to human skin tissue; The adhesion of the skin can be as high as 5.1 kPa, and the water absorption rate in 2 hours is 144.3%, which satisfy the basic requirements of skin wound repair dressing. Further rat skin wound repair experiments show that KTN/SA/PAM hydrogel skin dressings have better repairing ability than commercially available wound tapes and SA/PAM hydrogels. Histological analysis of wound skin tissue sections shows that after KTN/SA/PAM skin dressing treatment, the immature tissue areas of the wound were the smallest and the collagen fibers were arranged most neatly. After 14 days, the degree of wound healing was almost similar to that of normal skin. The results indicated that KTN/SA/PAM skin dressing may be a more promising skin wound repair dressing.