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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2018, Vol. 38 Issue (3): 70-75    DOI: 10.13523/j.cb.20180309
综述     
脂肪干细胞对神经创伤修复的研究进展*
刘亚楠1,路莉1*(),王学习2,吴勇杰1,刘霞2
1 兰州大学药理研究所 兰州 730000
2 兰州大学中西医结合研究所 甘肃省新药临床前研究重点实验室 兰州 730000
Research Pogress of Adipose Derived Stem Cells on Nerve Injury Repair
Ya-nan LIU1,Li LU1*(),Xue-xi WANG2,Yong-jie WU1,Xia LIU2
1 Department of Pharmacology,School of Medicine, Lanzhou University, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 730000, China
2 Institute of Integrative Traditional and Western Medicine,School of Medicine, Lanzhou University, Lanzhou　730000, China
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摘要：

在医学上,神经系统对神经损伤的自我修复能力往往有限。因此,探索有效修复损伤神经的方法已经成为近年来的研究热点。研究发现脂肪干细胞对各类损伤神经都有一定的修复作用,可作为修复神经损伤的种子细胞。脂肪干细胞不仅具有干细胞的特性而且还具有自身的优点;首先它属于成体细胞,来源于中胚层,具有多种分化的潜能;其次免疫原性较低,易于取材;另外脂肪干细胞移植后的风险较低,因此被认为是修复神经损伤的优秀种子细胞。就脂肪干细胞的特性及脂肪干细胞在神经创伤修复方面的研究进展和存在的问题进行综述。
关键词： 脂肪干细胞;  生长因子;  神经损伤修复    
Abstract:

In medicine, the ability of the nervous system to repair nerve damage is often limited. In recent years, it has been found that adipose derived stem cells (ADSCs) have repair effects on various types of nerve injury and can be the seed cells for nerve injury repair. Not only being as stem cells, ADSCs also have some exclusive advantages. ADSCs belong to adult cells, which derived from the mesoderm, with multi-lineage differentiation potential, low immunogenicity, easy to gain, low risk after transplantation, thus make them become excellent immunogenicity, easy to gain, low risk after transplantation, thus make them become excellent seed cells for the nerve repair.The characteristics of adipose derived stem cells and their research progress and existing problems on nerve injury repair were reviewed.
Key words: Adipose-derived stem cells    Growth factor    Nerve injury repair
收稿日期: 2017-08-17 出版日期: 2018-04-04
ZTFLH:  Q813  
基金资助: 兰州大学中央高校基本科研业务费专项资金(lzujbky-2016-65);兰州市城关区科技计划(2016-7-8);中央高校基本科研业务费专项资金(lzujbky-2014-214)
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刘亚楠
路莉
王学习
吴勇杰
刘霞

引用本文:

刘亚楠,路莉,王学习,吴勇杰,刘霞. 脂肪干细胞对神经创伤修复的研究进展*[J]. 中国生物工程杂志, 2018, 38(3): 70-75.

Ya-nan LIU,Li LU,Xue-xi WANG,Yong-jie WU,Xia LIU. Research Pogress of Adipose Derived Stem Cells on Nerve Injury Repair. China Biotechnology, 2018, 38(3): 70-75.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180309    或    https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I3/70

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