研究报告 |
|
|
|
|
慢病毒载体介导RAB27A基因过表达对人HepG2肝癌细胞增殖的影响 |
刘雪杰1,2, 林巍然2, 唐立春2, 孙薇2, 魏汉东2, 姜颖1,2 |
1. 安徽医科大学 合肥 230032;
2. 军事医学科学院放射与辐射医学研究所 蛋白质组学国家重点实验室 北京蛋白质组研究中心 北京 102206 |
|
Construction of Lentiviral Expression Vector Expressing Human RAB27A and Investigation Its Effect on the Proliferation of HepG2 Cell Lines |
LIU Xue-jie1,2, LIN Wei-ran2, TANG Li-chun2, SUN Wei2, WEI Han-dong2, JIANG Ying1,2 |
1. Graduate School, Anhui Medical University, Hefei 230032, China;
2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China |
引用本文:
刘雪杰, 林巍然, 唐立春, 孙薇, 魏汉东, 姜颖. 慢病毒载体介导RAB27A基因过表达对人HepG2肝癌细胞增殖的影响[J]. 中国生物工程杂志, 2014, 34(9): 16-23.
LIU Xue-jie, LIN Wei-ran, TANG Li-chun, SUN Wei, WEI Han-dong, JIANG Ying. Construction of Lentiviral Expression Vector Expressing Human RAB27A and Investigation Its Effect on the Proliferation of HepG2 Cell Lines. China Biotechnology, 2014, 34(9): 16-23.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20140904
或
https://manu60.magtech.com.cn/biotech/CN/Y2014/V34/I9/16
|
[1] Parkin D M, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians, 2005, 55(2): 74-108.
[2] Jemal A, Bray F, Center M M, et al. Global cancer statistics. CA: A Cancer Journal for Clinicians, 2011, 61(2): 69-90.
[3] El-Serag H B, Rudolph K L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 2007, 132(7): 2557-2576.
[4] Yang L, Parkin D M, Li L D, et al. Estimation and projection of the national profile of cancer mortality in China: 1991-2005. British Journal of Cancer, 2004, 90(11): 2157-2166.
[5] Aravalli R N, Steer C J, Cressman E N K. Molecular mechanisms of hepatocellular carcinoma. Hepatology, 2008, 48(6): 2047-2063.
[6] Ricke J, Seidensticker M, Mohnike K. Noninvasive diagnosis of hepatocellular carcinoma in cirrhotic liver: current guidelines and future prospects for radiological imaging. Liver Cancer, 2012, 1(1): 51-58.
[7] Walzer N, Kulik L M. Hepatocellular carcinoma: latest developments. Current Opinion in Gastroenterology, 2008, 24(3): 312-319.
[8] Blechacz B, Splinter PL, Greiner S, et al. Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. Hepatology, 2006, 44(6): 1465-1477.
[9] Fang Z L, Sabin C A, Dong B Q, et al. HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study. The American Journal of Gastroenterology, 2008, 103(9): 2254-2262.
[10] László L. Predictive and prognostic factors in the complex treatment of patients with colorectal cancer. Magyar Onkologia, 2010, 54(4): 383-394.
[11] Sterling R K, Wright E C, Morgan T R, et al. Frequency of elevated hepatocellular carcinoma (HCC) biomarkers in patients with advanced hepatitis C. The American Journal of Gastroenterology, 2011.
[12] Mamidipudi V, Zhang J, Lee K C, et al. RACK1 regulates G1/S progression by suppressing Src kinase activity. Molecular and Cellular Biology, 2004, 24(15): 6788-6798.
[13] Corbeel L, Freson K. Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders. European Journal of Pediatrics, 2008, 167(7): 723-729.
[14] Seabra M C, Mules E H, Hume A N. Rab GTPases, intracellular traffic and disease. Trends in Molecular Medicine, 2002, 8(1): 23-30.
[15] Stenmark H, Olkkonen V M. The rab gtpase family. Genome Biol, 2001, 2(5): S3007.
[16] Pfeffer S. A model for Rab GTPase localization. Biochemical Society Transactions, 2005, 33(4): 627-630.
[17] Zerial M, McBride H. Rab proteins as membrane organizers. Nature Reviews Molecular Cell Biology, 2001, 2(2): 107-117.
[18] Pereira-Leal J B, Seabra M C. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. Journal of Molecular Biology, 2000, 301(4): 1077-1087.
[19] Bem D, Yoshimura S I, Nunes-Bastos R, et al. Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome. The American Journal of Human Genetics, 2011, 88(4): 499-507.
[20] Verhoeven K, De Jonghe P, Coen K, et al. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. The American Journal of Human Genetics, 2003, 72(3): 722-727.
[21] Jenkins D, Seelow D, Jehee F S, et al. RAB23 mutations in carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. The American Journal of Human Genetics, 2007, 80(6): 1162-1170.
[22] Ménasché G, Pastural E, Feldmann J, et al. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nature Genetics, 2000, 25(2): 173-176.
[23] Giannandrea M, Bianchi V, Mignogna M L, et al. Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. The American Journal of Human Genetics, 2010, 86(2): 185-195.
[24] Huizing M, Helip-Wooley A, Westbroek W, et al. Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics. Annual Review of Genomics and Human Genetics, 2008, 9: 359.
[25] Anant J S, Desnoyers L, Machius M, et al. Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex. Biochemistry, 1998, 37(36): 12559-12568.
[26] Larijani B, Hume A N, Tarafder A K, et al. Multiple factors contribute to inefficient prenylation of RAB27A in Rab prenylation diseases. Journal of Biological Chemistry, 2003, 278(47): 46798-46804.
[27] Fukuda M. Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. Journal of Biochemistry, 2005, 137(1): 9-16.
[28] Wu X, Hu A, Zhang M, et al. Effects of RAB27A on proliferation, invasion, and anti-apoptosis in human glioma cell. Tumor Biology, 2013, 34(4): 2195-2203.
[29] Li W, Mu D, Tian F, et al. Exosomes derived from RAB27A?overexpressing tumor cells elicit efficient induction of antitumor immunity. Molecular Medicine Reports, 2013, 8(6): 1876-1882.
[30] Wang J S, Wang F B, Zhang Q G, et al. Enhanced expression of RAB27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II. Molecular Cancer Research, 2008, 6(3): 372-382.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|