技术与方法 |
|
|
|
|
头孢菌素C产生菌的诱变育种及培养基优化 |
黎亮, 王泽建, 郭美锦, 储炬, 庄英萍, 张嗣良 |
华东理工大学生物反应器工程国家重点实验室 国家生化工程技术研究中心 上海 200237 |
|
Mutagenesis Breeding and Optimization of Cephalosporin C by Cephalosporium acremonium |
LI Liang, WANG Ze-jian, GUO Mei-jin, CHU Ju, ZHUANG Ying-ping, ZHANG Si-liang |
State Key Lab of Bioreactor Engineering, National Engineering Research Center for Biotechnology, East China University of Science and Technology, Shanghai 200237, China |
引用本文:
黎亮, 王泽建, 郭美锦, 储炬, 庄英萍, 张嗣良. 头孢菌素C产生菌的诱变育种及培养基优化[J]. 中国生物工程杂志, 2014, 34(8): 61-66.
LI Liang, WANG Ze-jian, GUO Mei-jin, CHU Ju, ZHUANG Ying-ping, ZHANG Si-liang. Mutagenesis Breeding and Optimization of Cephalosporin C by Cephalosporium acremonium. China Biotechnology, 2014, 34(8): 61-66.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20140810
或
https://manu60.magtech.com.cn/biotech/CN/Y2014/V34/I8/61
|
[1] 祖玉梅. β-内酰胺类抗生素的应用与发展现状. 中国实用医药, 2010, 05(30): 246-248. Zu Y M. β-lactam antibiotics application and development. Practical Medicine in China, 2010, 05(30): 246-248.
[2] 薛雨, 陈宇瑛. 头孢菌素类抗生素的最新研究进展. 中国抗生素杂志, 2011, 36(2): 86-92. Xue Y, Chen Y Y.New development of cephalosporin antibiotics. Chinese Journal of Antibiotics, 2011, 36(2): 86-92.
[3] 郑琦. 头孢菌素类产品的市场情况及头孢菌素C发酵工艺. 海峡药学, 2010, 22(7): 38-40. Zheng Q. Cephalosporin products market situation and cephalosporin C fermentation technology. Strait Pharmaceutical Journal, 2010, 22(7): 38-40.
[4] Skatrud P L, Tietz A J, Ingolia T D, et al. Use of recombinant DNA to improve production of cephalosporin C by Cephalosporium acremonium. Nat Biotech, 1989, 7(5):477-485.
[5] Gutierrez S, Velasco J, Marcos A T, et al. Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. Appl Microbiol Biotechnol, 1997. 48(5):606-614.
[6] Ullán R, Liu G, Casqueiro J, et al. The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production. Mol Genet Genomics, 2002, 267(5):673-683.
[7] DeModena J A, Gutierrez S, Velasco J, et al. The production of cephalosporin C by Acremonium chrysogenum is improved by the intracellular expression of a bacterial hemoglobin. Biotechnology, 1993, 11(8):926-929.
[8] 胡又佳, 朱宝泉. 顶头孢霉遗传育种研究进展. 遗传, 2011, 33(10): 1079-1086. Hu Y J, Zhu B Q. Research progress on strain improvement of Acremonium chrysogenum by genetic engineering. Hereditas, 2011, 33(10): 1079-1086.
[9] 孟国庆, 赵林, 戴秀君, 等. 头孢菌素C高产菌株的推理选育. 中国抗生素杂志, 2011, 36(12):889-894, 951. Meng G Q, Zhao L, Dai X J, et al. Rational screening of eephalosporin C high yielding producing strains. Chinese Journal of Antibiotics, 2011, 36(12): 889-894, 951.
[10] 曹栋, 陈一鸣, 徐威. 紫外诱变和终产物抗性筛选头孢菌素C高产菌株. 沈阳药科大学学报, 2010, 27(06):495-498. Cao D, Chen Y M, Xu W.Breeding of high cephalosporin C2-producing strain by UV radiation and resistance of end metabolite. Journal of Shenyang Pharmaceutical University, 2010, 27(06):495-498.
[11] 唐敦武, 何建勇. 顶头孢霉的去代谢产物反馈调节选育模型的建立与应用. 沈阳药科大学学报, 2005, 22(4): 306-309. Tang D W, He J Y.Screening model setting of defeedback regulation of metabolite in Cephalosporium acremomium. Journal of Shenyang Pharmaceutical University, 2005, 22(4): 306-309.
[12] Tollnick C, Seidel G, Beyer M, et al. Investigations of the production of cephalosporin C by Acremonium chrysogenum. Adv Biochem Eng Biotechnol, 2004, 86: 1-45.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|