| 研究报告 |
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| 丝氨酸蛋白酶HtrA2/Omi可参与调节线粒体中的适配蛋白p66Shc |
| 刘姝1,2, 姜长安1,2 |
1. 四川大学华西第二医院 西部妇幼医学研究院 华西发育与干细胞研究所 成都 610041;
2. 四川大学华西医院 生物治疗国家重点实验室 成都 610041 |
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| Serine Protease Omi/HtrA2 Regulates Adaptor Protein p66Shc in Mitochondria |
| LIU Shu1,2, JIANG Chang-an 1,2 |
1. West China Development and Stem Cell Institute, West China Institute of Women and Children's Health, West China Second University Hospital, Chengdu 610041, China;
2. State Key Laboratory of Biotherapy, West China Hospital, Chengdu 610041, China |
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[16] Li B, Hu Q, Wang H, et al. Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death and Differentiation, 2010, 17(11): 1773-1784.
[17] Wieckowski M R, Giorgi C, Lebiedzinska M, et al. Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nature Protocol, 2009, 4(11): 1582-1590.
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