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鼠源原蛋白转化酶2基因的构建及其表达 |
吴爽1, 周东2, 张娟辉2, 唐松山1 |
1. 广东省生物活性药物重点实验室 广东药学院 广州 510006; 2. 广东省人民医院 广州 510080 |
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Construction and Expression of Rat Proprotein Convertase 2 Gene |
WU Shuang1, ZHOU Dong2, ZHANG Juan-hui2, TANG Song-shan1 |
1. Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China; 2. Department of Neurosurgery, Guangdong General Hospital, Guangzhou 510080, China |
引用本文:
吴爽, 周东, 张娟辉, 唐松山. 鼠源原蛋白转化酶2基因的构建及其表达[J]. 中国生物工程杂志, 2012, 32(08): 19-23.
WU Shuang, ZHOU Dong, ZHANG Juan-hui, TANG Song-shan. Construction and Expression of Rat Proprotein Convertase 2 Gene. China Biotechnology, 2012, 32(08): 19-23.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/
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https://manu60.magtech.com.cn/biotech/CN/Y2012/V32/I08/19
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[1] Abdel-Majid Khatib, Ge'raldine Siegfried. Proprotein convertases in tumor progression and malignancy. American Journal of Pathology, 2002,160(6):1921-1935. [2] Seidah N G, Prat A. Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem, 2002, 38:79-94. [3] Thomas G. Furin at the cutting edge: from protein trafic to embryogenesis and disease. Nat Rev Mol Cell Biol, 2002,3(10):753-766. [4] Taylor N A, Van De Ven W J, Creemers W J. Curbing activation: proprotein convertases in homeostasis and pathology. FASEB J, 2003,17:1215-1227. [5] Leak T S, Keene K L, Langefeld C D, et al. Association of the proprotein convertase subtilisin/ kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. Mol Genet Metab, 2007,92 (1-2):145-150. [6] Tian S, Jianhua W.Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. International Journal of Biological Sciences, 2010,6(1):89-95. [7] Seidah N G, Mowla S J, Hamelin J, et al. Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.Proc Natl Acad Sci USA, 1999, 96(4):1321-1326. [8] Sakai J, Rawson R B, Espenshade P J, et al. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol Cell, 1998, 2(4):505-514. [9] Ye J, Rawson R B, Komuro R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell, 2000, 6:1355-1364. [10] Shennan K I, Taylor N A, Jermany J L, et al. Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events, J Biol Chem, 1995,270(3):1402-1407. [11] Espinosa V P, Liu Y, Ferrini M, et al. Differential regulation of PC1/3,PC2 and phosphorylated creb by short-team and long-team morphine treatment: implication for understanding the "switch" to opiate addiction. Neuroscience, 2008,156(3): 788-799. [12] Bl醶quez M, Thiele C, Huttner W B, et al. Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway. Biochem J, 2000,349(8):843-852. [13] Tang S S, Zhang J H, Liu H X, et al. PC2 / CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues. Mol Cell Endocrinol, 2009, 303 (1-2): 43-49. [14] Furuta M, Zhou A, Webb G, et al.Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem, 2001,276 (29):27197-27202. [15] Benjannet S, Rondeau N, Day R, et al. PC1/3 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci, 1991, 88:3564-3568. |
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