| 研究报告 |
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| 重组PLZF蛋白锌指结构域的表达、提纯和活性分析 |
| 李伟 |
| 上海交通大学系统生物医学研究院 教育部系统生物医学重点实验室 上海 200240 |
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| Expression, Purification and Characterization of the Zinc Finger Domain of PLZF Protein |
| LI Wei |
| Shangahi Center for Systems Biomedicine, Key Laboratory of Systems Biomedicne, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China |
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[4] Li X, Peng H, Schultz D C, et al. Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res, 1999, 59(20):5275-5282.
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[7] Shaknovich R, Yeyati P L, Ivins S, et al. The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis. Mol Cell Biol, 1998, 18(9):5533-5545.
[8] Chauchereau A, Mathieu M, de Saintignon J, et al. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene, 2004, 23(54):8777-8784.
[9] Guidez F, Howell L, Isalan M, et al. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol, 2005, 25(13):5552-5566.
[10] Rho S B, Park Y G, Park K, et al. A novel cervical cancer suppressor 3 (CCS-3) interacts with the BTB domain of PLZF and inhibits the cell growth by inducing apoptosis. FEBS Lett, 2006, 580(17):4073-4080.
[11] Martin P J, Delmotte M H, Formstecher P, et al. PLZF is a negative regulator of retinoic acid receptor transcriptional activity. Nucl Recept, 2003,1(1):6.
[12] Li X, Lopez-Guisa J M, Ninan N, et al. Overexpression, purification, characterization, and crystallization of the BTB/POZ domain from the PLZF oncoprotein. J Biol Chem, 1997, 272(43):27324-27329.
[13] Cook M, Gould A, Brand N, et al. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc Natl Acad Sci U S A, 1995, 92(6):2249-2253.
[14] Raberger J, Schebesta A, Sakaguchi S, et al. The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. Proc Natl Acad Sci U S A, 2008, 105(46):17919-17924.
[15] Dick J E, Doulatov S. The role of PLZF in human myeloid development. Ann N Y Acad Sci,2009, 1176:150-153.
[16] Belak Z R, Nair M, Ovsenek N. Parameters for effective in vitro production of zinc finger nucleic acid-binding proteins. Biotechnol Appl Biochem, 2011, 58(3):166-174.
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