研究报告 |
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戊二醛聚合对猪、牛和人血红蛋白免疫学特性的影响 |
朱晓丽1, 王童文2 |
1. 西北大学 陕西省生物材料与发酵工程技术研究中心 西安 710127;
2. 西北大学 国家微检测系统工程技术研究中心 西安 710127 |
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The Influence of Glutaraldehyde Polymerization on Immunological Properties of Porcine Hemoglobin, Bovine Hemoglobin and Human Hemoglobin |
ZHU Xiao-li1, WANG Tong-wen2 |
1. Northwest University Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Xi'an 710127, China;
2. Northwest University National Engineering Research Center for Miniaturized Detection System, Xi'an 710127, China |
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[13] Schubert A, Przybelski R J, Eidt J F, et al. Diaspirin cross-linked hemoglobin reduces blood transfusion in noncardiac surgery: a multicenter, randomized, controlled, double-blinded trial. Anesth Analg, 2003,97:323-332.
[14] Estep T N, Gonder J, Bornstein I, et al. Immunogenicity of diaspirin cross-linked human hemoglobin solutions. Biomater Artif Cells Immobilization Biotechnol, 1992, 20(2-4): 603-609.
[15] 王军志.生物技术药物研究开发和质量控制. 北京:科学出版社,2002.721. Wang J Z. Research Development and Quality Control of Biotechnological Pharmaceutics. Science Press, 2002, 721.
[16] 朱晓丽. 戊二醛聚合猪血红蛋白氧载体免疫学特性及其作用机理的研究. 西安:西北大学,化工学院,2007. Zhu X L. The study of imunological properties and mechanisms of glutaraldehyde polymerized/modified porcine hemoglobin oxygen carrier. Xi'an: Northwest University, School of Chemical Engineering, 2007.
[17] Natanson C, Kern S J, Lurie P, et al. Cell free Hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA, 2008,299:2304-2312.
[18] Darin S K, Steven P W, Huang W, et al. Structure determination of aquomet porcine hemoglobin at 2.8A resolution. J Mol Biol, 1994, 244: 541-553. |
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