渔用菌蜕疫苗的研究进展

中国生物工程杂志

2013, Vol. 33

Issue (11): 112-117

综述

渔用菌蜕疫苗的研究进展

姜娜, 邢薇, 马志宏, 李铁梁, 罗琳

北京市农林科学院北京市水产科学研究所北京 100068

Research Progress in Aquaculture Ghost Vaccines

JIANG Na, XING Wei, MA Zhi-hong, LI Tie-liang, LUO Lin

Beijing Fisheries Research Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China

全文: PDF(425 KB) HTML

摘要： 菌蜕是革兰氏阴性菌被噬菌体PhiX174的裂解基因E裂解后形成的完整细菌空壳，以此菌蜕制备的疫苗为菌蜕疫苗，在最近几年刚开始用于鱼类细菌疫苗研究。由于菌蜕疫苗不仅具有很高的生物安全性，能诱导机体产生体液免疫和细胞免疫，而且能够在鱼类采用口服免疫的方式，因此在鱼类疫苗中有着得天独厚的优势。目前，菌蜕作为重组疫苗或药物递送体系也开始受到关注。文中综述了渔用菌蜕疫苗的国内外研究最新进展，探讨了采用不同策略免疫所产生免疫反应和保护性作用的强弱。

关键词： 菌蜕; 渔用疫苗; 递送载体

Abstract: Bacterial ghost, a novel inactivated non-denatured bacterium, is intact bacterial envelope which is lysised by the lysis gene E of PhiX174. Bacterial ghost has been researched as fish bacteria vaccine just in recent 8 years. It not only has high biological safety, but also can induce humoral and cellular immunity. So bacterial ghost is possible to be used in oral immunization and has a unique advantage in fish vaccine. Much more attention has been paid on ghost being used as a recombinant vaccine or drug delivery system. This paper summarizes the international latest developments in fish bacterial ghost vaccine, discusses their immune response and protective effect in different immunization ways using different strategies.

Key words: Ghost Aquaculture vaccines Delivery vector

收稿日期: 2013-07-24 出版日期: 2013-11-25

ZTFLH:

R979

基金资助: 北京市科技计划资助项目（D121100003712003）

通讯作者: 罗琳 E-mail: luo_lin666@sina.com

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引用本文:

姜娜, 邢薇, 马志宏, 李铁梁, 罗琳. 渔用菌蜕疫苗的研究进展[J]. 中国生物工程杂志, 2013, 33(11): 112-117.

JIANG Na, XING Wei, MA Zhi-hong, LI Tie-liang, LUO Lin. Research Progress in Aquaculture Ghost Vaccines. China Biotechnology, 2013, 33(11): 112-117.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2013/V33/I11/112

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