n-3多不饱和脂肪酸是机体脂肪酸成分之一，维持体内合理的n-3多不饱和脂肪酸比例具有重要的生理意义。但n-3多不饱和脂肪酸在大多数动物体内不能合成，只能从食物中补充。fat-1基因的出现改变了这一现状，它可以将多不饱和脂肪酸从n-6形式转化为n-3形式。文章综述了n-3多不饱和脂肪酸的功能，并介绍了fat-1基因的功能及转fat-1基因动物在n-3多不饱和脂肪酸功能研究上的应用。
N-3 polyunsaturated fatty acids (PUFAs) is an important component of the fatty acid. It is necessary to maintain the appropriate proportion of n-3 PUFAs physiological. However most animals have to obtain n-3 PUFAs from diet,because they can not synthesize them by themselves.Fat-1 gene, translating into ω-3 PUFA desaturase, can convert PUFAs from n-6 to n3 form. The main functions of n-3 PUFAs, and the applications and potential of the fat-1 in n-3 PUFAs research are reviewed in this paper.
武珅,杜卫华,郝海生,王栋,张诺,朱化彬. Fat-1基因在n-3多不饱和脂肪酸功能研究中的应用[J]. 中国生物工程杂志, 2008, 28(8): 136-141.
. Applications of the fat-1 in n-3 PUFAs Function Research. China Biotechnology, 2008, 28(8): 136-141.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2008/V28/I8/136
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