肿瘤的早期诊断和靶向治疗是肿瘤能否成功治疗的关键所在。由于缺少合适的靶向载体,肿瘤早期诊断和靶向治疗效果还不够理想。肽作为肿瘤显像剂和导向治疗靶试剂不仅具有药物代谢动力学的优势,而且利用噬菌体展示技术易于得到肽序列。目前,应用噬菌体展示技术对不同肿瘤,肿瘤细胞,肿瘤转移相关的粘附分子、新生血管等进行筛选,至少已鉴定出1000多种特异性结合肽。
The early recognition of the primary tumor and targeting agents to tumor are critical to successful treatment. The primary diagnostic cancer and targeting treatment are still not effective enough, because excellent targeting agents are rather scarce. Peptides possess not only appropriate pharmacokinetic properties to serve tumor imaging or therapeutic targeting agents, but also easily deduce peptide residues using phage display technology. Up till present moment, more than 1000 peptides have been identified targeting to tumors, tumor cells, cognate molecules with metastasis and angiogenic vessels.
孙丽艳. 肽在肿留早期诊断及靶向治疗中的应用[J]. 中国生物工程杂志, 2006, 26(0): 195-198.
. Application of Peptides in early recognition of the primary tumor and targeting agents ot tumor. China Biotechnology, 2006, 26(0): 195-198.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I0/195
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