摘要:葡激酶是由溶原性葡萄球菌分泌的一种具有潜在溶栓功能的含有136个氨基酸的蛋白质。SAK与纤溶酶原（Plg）形成1：1复合物，使后者转变为纤溶酶（Plm）后发挥溶栓作用。作为新一代溶栓剂，SAK以其专一性高，出血副作用小的特点受到人们的广泛关注。本文从SAK的结构、生物学特性及机理、基因克隆及表达方面的研究进展等方面进行了综述。
Abstract:Staphylokinase(SAK) is a 136-amino acid protein,secreted by certain strains of lysogenesis Staphylococci with thrombolytic potential.It combined with Plg to form 1:1 composite, then it made later into Plm and brought into play a role of thrombolysis. As a new thrombolytics, SAK is payed close attention because of high specificity、little bad role of thrombolysis. This review introduced the structure 、biologic activities and their mechanism of SAK, SAK’s gene cloning and expression research concerned.
刘敏. 葡激酶及其基因工程的研究进展[J]. 中国生物工程杂志, 2006, 26(0): 226-229.
. Advances in Research of Staphylokinase. China Biotechnology, 2006, 26(0): 226-229.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I0/226
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