北京外来入侵植物刺萼龙葵抑肿瘤ATPase效应评估

中国生物工程杂志

2010, Vol. 30

Issue (12): 36-41

研究报告

北京外来入侵植物刺萼龙葵抑肿瘤ATPase效应评估

梁前进^1,2, 李翠妮^1,2, 向俊¹, 刘全儒¹, 周云龙¹, 孙乐³, 毛春明³

1. 北京师范大学生命科学学院基因工程药物及生物技术北京市重点实验室北京 100875;
2. 北京师范大学细胞增殖与调控教育部重点实验室北京 100875;
3. 京天成生物技术北京有限公司北京 100085

An Assessment of the Inhibiting Effect of the Beijing Invasive Plant Solanum rostratum on Tumor ATPase

LIANG Qian-jin^1,2, LI Cui-ni^1,2, XIANG Jun¹, LIU Quan-ru¹, ZHOU Yun-long¹, SUN Le³, MAO Chun-ming³

1. College of Life Sciences, Beijing Normal University, Beijing Key Laboratory, Beijing 100875,China;
2. Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education of China, Beijing 100875,China;
3. AbMax Biotechnology Co., Beijing 100085, China

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摘要：

在北京,本世纪初出现了一种外来入侵植物——刺萼龙葵。这种植物起源于北美洲,全植株有毒,含有茄碱(一种神经毒素);另一方面,茄碱又有抑瘤等功效。为了在熟悉刺萼龙葵的毒害程度、治理这种外来入侵植物的同时,能够废物利用,从中有效获得茄碱等有药理或经济价值的成分,通过检测全植株提取物对肿瘤细胞(H₂₂)膜ATPase活力的抑制效应,并对照茄碱、传统化疗药物环磷酰胺的功效,对北京外来入侵植物刺萼龙葵抑瘤效应进行了评估。结果发现,北京自然界已入侵生长的刺萼龙葵的细胞毒性约相当于3.63 mg/g茄碱的当量,大约相当于(或略高于)马铃薯嫩芽的茄碱当量。因此,实行废物利用,从入侵生长的刺萼龙葵中获得茄碱(等药用成分)大有作为,可以在治理生态中获得经济效益,并解放出马铃薯等具有其他重要经济价值作物的生产力。

关键词： 刺萼龙葵; 外来入侵植物; 抑瘤效应; 茄碱(龙葵碱)

Abstract:

In Beijing, there has emerged an external invasion plant, Solanum rostratum dating from the beginning of this century. This plant originated from the North America. It is poisonous all over the body. There exists a sort of neurotoxin, solanine in Solanum rostratum. On the other hand, solanine is also a valuable material that, for example, is effective for inhibiting tumors. In order to utilize waste materials by obtaining pharmacologically and economically valuable products such as solanine from Solanum rostratum as well as becoming familiar with its toxic degree and tackling with this external invasion plant. It was designed to assess the tumor suppressing effect of Solanum rostratum by detecting the inhibiting effect of the whole-plant extract on the membrane ATPase activity of mouse tumor cell H22, with the functional effects of solanine and traditional chemotherapeutic cyclophosphamide as controls. The result revealed, in the nature of Beijing, the growing Solanum rostratum arising from invading expressed a tumor cell membrane ATPase activity inhibiting effect around as high as that of 3.63 mg/kg solanine, and around as high as or slightly higher than that of potato budlet equivalent. Therefore, it is possibly opportune to utilize waste material during renovating the ecology destroyed by the invading Solanum rostratum through obtaining medical components like solanine. It would be an economically efficient reaction, in the meanwhile emancipating the productive forces of potato and other valuable Solanum plants.

Key words: Solanum rostratum External invasion plant Tumor suppressing effect Solanine

收稿日期: 2010-08-31 出版日期: 2010-12-25

ZTFLH:

Q819

基金资助:

北京市自然科学基金(8082016)、北京市优秀人才培养资助基金(20081B0503100259)、国家自然科学基金(30771101,30971470)资助项目

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引用本文:

梁前进, 李翠妮, 向俊, 刘全儒, 周云龙, 孙乐, 毛春明. 北京外来入侵植物刺萼龙葵抑肿瘤ATPase效应评估[J]. 中国生物工程杂志, 2010, 30(12): 36-41.

LIANG Qian-jin, LI Cui-ni, XIANG Jun, LIU Quan-ru, ZHOU Yun-long, SUN Le, MAO Chun-ming. An Assessment of the Inhibiting Effect of the Beijing Invasive Plant Solanum rostratum on Tumor ATPase. China Biotechnology, 2010, 30(12): 36-41.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2010/V30/I12/36

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