骨髓间充质干细胞是骨髓基质的祖先细胞，具有多向分化的能力。近年来，它在免疫调节方面的作用越来越受到人们重视。体内和体外实验显示，MSCs具有抑制淋巴细胞增殖的免疫抑制作用。关于其在免疫抑制方面的作用机制的研究，目前的结论均不甚一致。可溶性细胞因子、细胞表面分子、吲哚胺2，3－二氧化酶、抗原递呈细胞和接触作用、细胞周期阻滞及MSCs诱导的淋巴细胞凋亡均可能参与了MSCs的免疫抑制作用。
Mesenchymal stem cells (MSCSs) are progenitor cells of the bone marrow stroma and have capacity of multilineage differentiation. Recently, their functions of immune regulation are being addressed enthusiastically which may relate to various factors: immune molecules expressed on MSCSs surface, their biding bility to immune effect cells and their functions on immune cells. Up to now, acknowledges of the mechanisms of MSCSs immune functions are not consistent. Soluble cytokines, cell surface molecules, IDO, cell contact, cell cycle arrest and antigen presenting cells might involved in the suppression of immune system.
曾婷婷,贾永前. 骨髓间充质干细胞的免疫调节机制研究进展[J]. 中国生物工程杂志, 2006, 26(0): 182-185.
. Recent Advances on Immuno-regulating Mechanisms of Marrow-derived Mesenchymal Stem Cells. China Biotechnology, 2006, 26(0): 182-185.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I0/182
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