原核生物中蛋白质乙酰化修饰的研究进展

中国生物工程杂志

2013, Vol. 33

Issue (9): 79-84

综述

原核生物中蛋白质乙酰化修饰的研究进展

毕静, 张雪莲

复旦大学生命科学学院上海 200433

Protein Acetylation in Prokaryotes

BI Jing, ZHANG Xue-lian

School of Life Sciences, Fudan University, Shanghai 200433, China

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摘要： 近来发现,除组蛋白外,大量非组蛋白也存在赖氨酸乙酰化,并广泛参与细胞分化、细胞代谢等重要生理活动,赖氨酸乙酰化已成为生命科学领域研究的前沿热点。已有很多研究证据表明原核生物也普遍存在蛋白质乙酰化修饰现象,而且涉及中心代谢和中间代谢的很多代谢酶都存在乙酰化修饰现象。为更好了解乙酰化修饰在细菌中的重要性,对目前原核生物中蛋白质乙酰化修饰研究内容和最新进展进行综述,归纳原核生物蛋白赖氨酸位点的可逆乙酰化在中心代谢途径等重要生理活动中的调控作用。

关键词： 乙酰化赖氨酸原核生物

Abstract: In addition to histones, recent evidences suggest many non-histone proteins are subject to lysine acetylation. Furthermore, lysine acetylation status has been shown to influence several fundamental cellular pathways, including cellular differentiation and metabolism. Protein lysine acetylation and its regulatory enzymes have thus emerged as a frontier for research in mammalian cells. Recent studies support that protein acetylation occurs prevalently in prokaryotes and broadly impacts prokaryotes physiology. An emerging theme from these studies is that metabolic enzymes involved in central metabolic pathways and intermediary metabolisms are subjected to acetylation. To explore more rapidly the impact of protein acetylation in bacteria, we will summarize the current examples of protein acetylation in prokaryotes, discuss the emerging link between acetylation and central metabolism and understand the importance of protein acetylation in bacteria.

Key words: Acetylation Lysine Prokaryote

收稿日期: 2013-02-25 出版日期: 2013-09-25

ZTFLH:

Q51

基金资助: 国家自然基金资助项目(81261120558、30901828)

通讯作者: 张雪莲xuelianzhang@fudan.edu,cn E-mail: xuelianzhang@fudan.edu,cn

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引用本文:

毕静, 张雪莲. 原核生物中蛋白质乙酰化修饰的研究进展[J]. 中国生物工程杂志, 2013, 33(9): 79-84.

BI Jing, ZHANG Xue-lian. Protein Acetylation in Prokaryotes. China Biotechnology, 2013, 33(9): 79-84.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2013/V33/I9/79

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