综述 |
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长效干扰素研究进展 |
田硕1,徐晨2*,姚文兵1 |
1.中国药科大学 南京 210009
2.北京三元基因工程有限公司 北京 102600 |
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The Advance in Long Effect Interferon Reserch |
TIAN Shuo1,XU Chen2,YAO Wen-bing1 |
1.School of Science & Technology,China Pharmaceutical University, Nanjing 210009,China
2.Beijing TriPrime Genetic Engineering Co.Ltd.,Beijing102600,China |
[1] Roberts M J,Bentley M D,Harris J M. Chemistry for peptide and protein PEGylation.Adv Drug Deliv Rev,2002,54(4):459476.
[2] Wang Y S,Yongster S,Grace M,et al. Structural and biological characterization of pegylated recombinant interferon alpha2b and its therapeutic applications.Adv Drug Deliv Rev, 2002, 54(4):547570.
[3] Reddy K R, Modi M W, Pedder S. Use of peginterferon alfa2a (40KD) (Pegasys) for the treatment of hepatitis C. Adv Drug Deliv Rev, 2002,54,571584.
[4] Harris J M, Martin N E, Modi M. Pegylationa novel process for modifying pharmacokinetics. Clin Pharmacokinet,2001,40(7):539551.
[5] Ramon J, Saez V, Baez R, et al. PEGylated interferonalpha2b: a branched 40K polyethylene glycol derivative. Pharm Res,2005, 22(8):13741386.
[6] Jo Y W, Youn Y S, Lee S H, et al. Longacting interferonalpha2a modified with a trimerstructured polyethylene glycol: preparation, in vitro bioactivity, in vivo stability and pharmacokinetics. Int J Pharm, 2006, 309(12):8793.
[7] Bell S J, Fam C M, Chlipala E A, et al. Enhance Circulating HalfLife and Antitumor Actiity of a SiteSpecific Pegylated Interferonα Protein Therapeutic. Bioconjugate Chem, 2008,19(1):299305.
[8] Balan S, Choi J W, Godwin A, et al. SiteSpecific PEGylation of Protein Disulfide Bonds Using a ThreeCarbon Bridge. Bioconjugate Chem, 2007,18(1):6176.
[9] 牛晓霞,刘金毅,杨轶,等. 集成干扰素突变体Ⅱ的分子构建、表达及提纯. 中国生物工程杂志, 2006,26(12):15. Niu X X , Liu J Y , Yang Y . Chin Biotechnol,2006,26(12):15.
[10] 牛晓霞,周敏毅,刘金毅,等. 聚乙二醇定点修饰集成干扰素突变体Ⅱ.中国生物工程杂志,2008,28(4):1720. Niu X X , Zhou M Y, Liu J Y,et al . Chin Biotechnol, 2008,28(4):1720.
[11] Bain V G,Kaita K D,Yoshida E M. A phase 2 study to evaluate the antiviral activity, safety,and pharmacokinetics of recombinant human albumininterferon alfa fusion protein in genotype 1 chronic hepatitis C. patients. J Hepatol,2006, 44(4):671678.
[12] Zhao H L, Xue C, Wang Y, et al. Circumventing the heterogeneity and instability of human serum albumininterferonalpha2b fusion protein by altering its orientation. J Biotechnol. 2007,131(3):245252.
[13] Zhao H L, Xue Q Y, Xue C, et al. Increasing the homogeneity, stability and activity of human serum albumin and interferonα2b fusion protein by linker engineering. Protein Express Purif ,2008, 61(1):7377.
[14] 王磊,何剑,肖卫华. 毕赤酵母表达人干扰素α 2b和人IgG免疫球蛋白Fc片段融合蛋白显著延长体内半衰期. 生物工程学报, 2008, 24(1):5362. Wang L, He J, Xiao W H. Chin J Biotechnol, 2008, 24(1):5362.
[15] Jones T D, Hanlon M, Smith B J, et al. The development of a modified human IFNalpha2b linked to the Fc portion of human IgG 1 as a novel potential therapeutic for the treatment of hepatitis C virus infection. J. Interferon Cytokine Res, 2004, 24(9): 560572.
[16] Ceaglio N, Etcheverrigaray M, Kratje R, et al. Novel longlasting interferon alpha derivatives designed by glycoengineering. Biochimie,2008,90 (3):437449.
[17] Drittanti L, Borrelly G, Guyon T, et al. Belerofon:a longlasting and orally available singleamino acid mutant of interferon alpha. J Interferon Cytokine Res , 2007,27:7091709.
[18] De Leede L G, Humphries J E, Bechet A C, et al.Novel ControlledRelease LemnaDerived IFNalpha2b (Locteron):Pharmacokinetics, Pharmacodynamics, and Tolerability in a Phase I Clinical Trial. J Interferon Cytokine Res , 2008,28(2):113122.
[19] Chan Y P, Meyrueix R, Kravtzoff R et al. Review on Medusa:a polymerbased sustained release technology for protein and peptide drugs. Expert Opin Drug Deliv , 2007, 4(4):441451.
[20] Zhang Y M, Yang F, Yang Y Q, et al. Recombinant interferonalpha2b poly(lacticcoglycolic acid) microspheres: pharmacokineticspharmacodynamics study in rhesus monkeys following intramuscular administration. Acta Pharmacol Sin,2008,29(11):13701375.
[21] Vyas S P, Rawat M, Rawat A, et al. Pegylated protein encapsulated multivesicular liposomes: a novel approach for sustained release of interferon alpha. Drug Dev Ind Pharm, 2006, 32(6):699707.
[22] Ito Y, Saeki A, Shiroyama K, et al. Percutaneous absorption of interferonα by selfdissolving micropiles. J Drug Target, 2008,16(3):243249. |
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