L-苯丙氨酸是人体必须但自生无法合成的八种必需氨基酸之一，是一种重要的医药和食用化学品中间体。到2005年，全球对L-苯丙氨酸的需求量达到3万吨，市场潜力巨大。特别是近年来，随着阿斯巴甜的全球热销以及底物反式肉桂酸生产成本的降低，利用苯丙氨酸解氨酶转化反式肉桂酸合成L-苯丙氨酸的生产工艺成为研究的热点。本文就苯丙氨酸解氨酶酶法合成L-苯丙氨酸的研究进展做了详细的阐述。
L-phenylalanine (L-Phe) is one of essential amino acids for humans. It is an important chemical intermediate in medicine and food industry. There is a huge market for L-Phe. The demand of L-Phe in all over the world reach 30000 ton in 2005. Especially, phenylalanine ammonia lyase (PAL) catalyzing trans-cinnamic acid (t-CA) to L-Phe method become hotspot in the production of L-Phe due to great demand for artificial sweetener aspartame and the descrease of the cost of tran-cinnamic acids. In the paper, we summarize the progress in the production of L-phenylalanine by using PAL.
崔建东,张亚楠. 苯丙氨酸解氨酶（PAL）酶法合成L-苯丙氨酸的研究进展[J]. 中国生物工程杂志, 2008, 28(专刊): 301-305.
. Advance in the production of L-phenylalanine by using phenylalanine ammonia lyase (PAL). China Biotechnology, 2008, 28(专刊): 301-305.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2008/V28/I专刊/301
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