高度不饱和脂肪酸（Highly unsaturated fatty acids, HUFAs），特别是ω-3HUFAs，是人和动物包括水产动物所必需的，在机体发挥重要的生理功能。所谓"必需"，是人和动物不能自行合成或合成不能满足其需要，必须从食物中摄取的物质。机体之所以依赖外源HUFAs，因其缺乏合成HUFAs所需的一或多种脂肪酸去饱和酶或酶活性低所致。因此，研究合成HUFAs去饱和酶成为当前热点之一。本文综述了合成HUFAs去饱和酶的分子生物学，特别是去饱和酶的结构和功能
Highly unsaturated fatty acids（HUFAs），especially ω-3HUFAs, are essential nutricients and play many physiological roles in human being and animals, including hydro-animal. However, the organisms depend on dietary HUFAs because of deficiency in the activity of one or more of the key fatty acid desaturases required for HUFAs synthesis, resulting in the desaturase study to be one of the heatst fields at the moment. The present paper reviews the recent progress in the studies of molecular biology of the desaturases of HUFA biosynthesis, emphasis on the structure and fuction of the desaturases.
丁兆坤,许友卿. 合成高度不饱和脂肪酸去饱和酶的分子生物学研究I.结构与功能[J]. 中国生物工程杂志, 2008, 28(专刊): 201-214.
. Studies on Molecular Biology of the Desaturases of Highly Uunsaturated Fatty Acid Biosynthesis I. Structure and Functions. China Biotechnology, 2008, 28(专刊): 201-214.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2008/V28/I专刊/201
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