中国生物工程杂志

Nowadays, the synthesis of polyamidoamine denerimers includes "solid phase synthesis" and "liquid phase synthesis". A new thought of synthesis polyamidoamine denerimer by fall together this two advantage is introduced. Having glycin as the core, a new fan-shape polyamidoamine denerimers are synthesized. The Fluorescence and Release Property are being studied too. The dendrimer were then reacted with 1- acetic-5-fluorouracil to form dendrimer-5FU conjugates. Hydrolysis of the conjugates in a phosphate buffer solution (pH 7.4) at 37℃ will release free 5FU. The dendrimer seems to be a promising carrier for the controlled release of anti-tumor drugs.