中国生物工程杂志

It's commonly accepted that the infection of HPV with high-risk is the important factor in the occurrence of cervix cancer. Recombinate technologies are used to develop HPV vaccines, which is the only effective method to prevent cervix cancer so far. From the both aspects of expression vectors and codon optimization, this article reviewed the widely used expression vectors in recent years and their characteristics ；as well as the research results on obviously enhancement of capsid protein by optimizing the virus capsid gene according to codon preference, which provide basis for the further manufacturing and optimization of HPV vaccines.