
多肽、蛋白类药物脂质体的研究进展
The Development of Liposomes of Peptides and Protein Drugs
脂质体做为多肽、蛋白类药物一种新型给药载体有控制药物释放、降低药物的毒性、提高药物的靶向性等突出优点,具有广阔的应用前景。本文通过查阅近10年来多肽和蛋白类药物脂质体研究的相关资料,总结论述了脂质体作为多肽、蛋白类药物载体在新的制备方法、新型脂质体、给药途径、产业化进展四个方面的最新研究动向,指出了多肽、蛋白类药物脂质体在研究应用中存在的不足,并展望了多肽、蛋白类药物脂质体未来发展的方向。
As an application of peptides and protein drug- delivery system, liposome is a kind of promising, broadly applicable drug-delivery system. It can control the drug releasing、deduce the drug toxicity、have the target proerty and so on. In this article , the mainly development including the methods of preparation, new liposomes, administeration of peptides and protein liposomes, was reviewed, according to the references of the development of peptides and protein liposomes in recent 10 years, Furthermore, the updated progresses of liposome of peptides and protein drugs were described, in order to provide some references to the research on liposome in biological area. Some problems in this drug- delivery system were also put forward. Although liposome has made considerable progress and development in the biological area, there are many technological tough problems have not been tackled. The further research on peptides and protein liposomes is also needed.
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